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Volume 10, Number 10—October 2004

Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance

Laurence Huang*Comments to Author , Kristina Crothers*, Chiara Atzori†, Thomas Benfield‡, Robert Miller§, Meja Rabodonirina¶, and Jannik Helweg-Larsen#
Author affiliations: *University of California San Francisco, San Francisco, California, USA; †Luigi Sacco Hospital, Milan, Italy; ‡HS Rigshospitalet, Copenhagen, Denmark; §University College London, London, United Kingdom; ¶Hôspital de la Croiz-Rousse, Lyon, France; #Hvidovre University Hospital, Copenhagen, Denmark

Main Article

Table 1

Amino acid substitutions observed in Pneumocystis jirovecii a

DHPS genotype Amino acid 
position 55 Amino acid 
position 57
  1 Threonine Proline
  2 Alanine Proline
  3 Threonine Serine
  4 (double mutant) Alanine Serine
  5 Threonine Proline/serine
  6 Threonine/alanine Proline/serine
  7 Threonine/alanine Proline
  8 Alanine Proline/serine

aDHPS, dihydropteroate synthase.

Main Article

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Page updated: April 07, 2011
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