, J.W.M. Lee*, M.L.N. Leong*, A.-E. Ling†, H.-C. Tan‡, and E.E. Ooi‡
Figure 3. Scanning electron microscopy of Vero E6 cells infected with severe acute respiratory syndrome–associated coronavirus at 24 h after infection. A) Cell surface is covered with extracellular progeny virus particles, and progeny virus are being extruded from or attached to numerous pseudopodia on infected cell surface (arrows). B) A higher magnification micrograph of the virus-clustered pseudopodia (arrows). C) Rosettelike appearance of the matured virus particles (arrows). The scanning electron microscopy image complements the form and structure of the virus seen with negative staining (inset) under transmission electron microscopy. Short and stubby spikes are visible on the virus surface.