Volume 10, Number 2—February 2004
THEME ISSUE
2004 SARS Edition
Laboratory Study
Interferon-β 1a and SARS Coronavirus Replication
Figure 1

Figure 1. Interferon (IFN)-β 1a inhibition of SARS-CoV replication in Vero E-6 cells. Top panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 24 h before infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Bottom panels, Vero E-6 cells were incubated in the absence (-▲-) or presence of IFN-β 1a added 1 h after infection with the Tor2 (left) or Tor7 (right) isolate of SARS Co-V. Three concentrations of IFN-β 1a were employed for both studies: 5,000 IU/mL (-□-), 50,000 IU/mL (-■-), 500,000 IU/mL (-■-) Samples of overlying media were collected at 24, 48, and 72 h postinfection and analyzed by plaque assay on Vero E-6 cells.