TY - JOUR AU - Weingartl, Hana M. AU - Copps, John AU - Drebot, Michael A. AU - Marszal, Peter AU - Smith, Greg AU - Gren, Jason AU - Andonova, Maya AU - Pasick, John AU - Kitching, Paul AU - Czub, Markus T1 - Susceptibility of Pigs and Chickens to SARS Coronavirus T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 2 SP - 179 SN - 1080-6059 AB - An outbreak of severe acute respiratory syndrome (SARS) in humans, associated with a new coronavirus, was reported in Southeast Asia, Europe, and North America in early 2003. To address speculations that the virus originated in domesticated animals, or that domestic species were susceptible to the virus, we inoculated 6-week-old pigs and chickens intravenously, intranasally, ocularly, and orally with 106 PFU of SARS-associated coronavirus (SARS-CoV). Clinical signs did not develop in any animal, nor were gross pathologic changes evident on postmortem examinations. Attempts at virus isolation were unsuccessful; however, viral RNA was detected by reverse transcriptase-polymerase chain reaction in blood of both species during the first week after inoculation, and in chicken organs at 2 weeks after inoculation. Virus-neutralizing antibodies developed in the pigs. Our results indicate that these animals do not play a role as amplifying hosts for SARS-CoV. KW - severe acute respiratory syndrome KW - coronavirus KW - experimental infection KW - swine KW - chicken KW - Canada DO - 10.3201/eid1002.030677 UR - https://wwwnc.cdc.gov/eid/article/10/2/03-0677_article ER - End of Reference