TY - JOUR AU - Albrich, Werner C. AU - Monnet, Dominique L. AU - Harbarth, Stephan T1 - Antibiotic Selection Pressure and Resistance in Streptococcus pneumoniae and Streptococcus pyogenes T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 3 SP - 514 SN - 1080-6059 AB - We correlated outpatient antibiotic use with prevalence of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP), macrolide-resistant S. pneumoniae (MRSP), and macrolide-resistant S. pyogenes (MRGAS) in 20 countries. Total antibiotic use was correlated with PNSP (r = 0.75; p < 0.001), as was macrolide use with MRSP (r = 0.88; p < 0.001) and MRGAS (r = 0.71; p = 0.004). Streptococcal resistance is directly associated with antibiotic selection pressure on a national level. KW - antibiotics KW - drug resistance, microbial KW - epidemiology KW - Streptococcus pneumoniae KW - Streptococcus pyogenes DO - 10.3201/eid1003.030252 UR - https://wwwnc.cdc.gov/eid/article/10/3/03-0252_article ER - End of Reference