, Filippo Canducci*, Debora Pinna*, Nicasio Mancini*, Silvia Carletti*, Adriano Lazzarin*†, Claudio Bordignon*†, Guido Poli*†, and Massimo Clementi*†
Figure 1. Cytopathic effect (CPE) of primary severe acute respiratory syndrome–associated coronavirus strain HSR1 isolate. A, uninfected Vero cells form a continuous monolayer of spindle-shaped cells. B, a strong CPE was observed after 24 hours of incubation of Vero cells with the patient sputum sample (primary isolate).