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Volume 10, Number 4—April 2004
Research

Antigenic and Genetic Variability of Human Metapneumoviruses

Bernadette G. van den Hoogen*, Sander Herfst*, Leo Sprong*, Patricia A. Cane†, Eduardo Forleo-Neto‡, Rik L. de Swart*, Albert D.M.E. Osterhaus*, and Ron A.M. Fouchier*Comments to Author 
Author affiliations: *Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; †University of Birmingham Medical School, Birmingham, United Kingdom; ‡Vigi Virus, São Paulo, Brazil

Main Article

Table 3

Homologous and heterologous virus neutralizing antibody titers of sera obtained from ferrets infected with HMPV viruses belonging to different genetic sublineagesa,b

Virus used in virus neutralization Ferret 3 NL/1/00 [A1] Ferret 4 NL/17/00 [A2] Ferret 5 NL/1/99 [B1] Ferret 6 UK/5/01 [B2]
NL/ 1/00
256
256
6
32
NL/17/00
512
768
12
24
NL/ 1/99
16
32
256
384
UK/ 5/01
12
64
256
512
Ratio A–B
Ratio B–A 16–21 12–24 21–43 16–21

aVirus neutralizing antibody titers obtained for sera collected 21 days post infection from ferrets 3 to 6 (infected with NL/1/00, NL/17/00, NL/1/99 and UK/5/01, respectively). HMPV, human metapneumovirus.
bHomologous virus neutralization titers are bold. Values are average of duplicate measurements. Ratios are given as the homologous virus neutralization titers divided by the heterologous virus neutralization titers.

Main Article

Page created: February 09, 2011
Page updated: February 09, 2011
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