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Volume 10, Number 4—April 2004
Research

Inhibition of SARS Coronavirus Infection In Vitro with Clinically Approved Antiviral Drugs

Emily L.C. Tan*, Eng Eong Ooi†, Chin-Yo Lin*, Hwee Cheng Tan†, Ai Ee Ling‡, Bing Lim*, and Lawrence W. Stanton*Comments to Author 
Author affiliations: *Genome Institute of Singapore, Singapore; †National Environmental Agency, Singapore; ‡Singapore General Hospital, Singapore

Main Article

Table 1

Commercially available antiviral agents tested, source and starting concentration

Antiviral agent Source Highest concentration tested Inhibition of cytopathic effect (CIA100)
Interferons
Interferon α-2a (Roferon)
Roche
100,000 IU/mL
No
Interferon α-2b (Intron A)
Schering-Plough
500,000 IU/mL
No
Interferon α-n1 (Wellferon)
GlaxoSmithKline
500,000 IU/mL
Yes
Interferon α-n3 (Alferon)
Hemispheryx
10,000 IU/mL
Yes
Interferon β-1a (Rebif)
Serono
500,000 IU/mL
No
Interferon β-1b (Betaferon)
Schering AG
100,000 IU/mL
Yes
Nucleoside analogs
Acyclovir
Faulding
1,000 μg/ml
No
Cymevene (Ganciclovir)
Roche
50,000 μg/mL
No
Ribavirin
ICN Pharma
10,000 μg/mL
Yes
Protease inhibitors
Indinavir (Crixivan)
Merck
100 μM
No
Nelfinavir (Viracept)
Roche
10,000 nM
No
Saquinavir (Fortovase)
Roche
10,000 nM
No
Reverse transcriptase inhibitors
Lamivudine (Epivir)
GlaxoSmithKline
1,000 μM
No
Zidovudine (Retrovir)
GlaxoSmithKline
1,000 μg/mL
No
Neuraminidase inhibitors
Oseltamivir (Tamiflu)
Roche
10,000 μM
No
Zanamivir (Relenza)
GlaxoSmithKline
1,000 μM
No
Other
Amantadine (Symmetrel)
Novartis
1,000 μg/mL
No
Foscarnet (Foscavir) AstraZeneca 8,000 μM No

Main Article

Page created: February 09, 2011
Page updated: February 09, 2011
Page reviewed: February 09, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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