Volume 10, Number 4—April 2004
Letter
Mycobacterium tuberculosis Complex Drug Resistance in Italy
Giovanni B. Migliori*, Rosella Centis*, Lanfranco Fattorini*, Giorgio Besozzi*, Cesare Saltini*, Claudio Scarparo*, Daniela Cirillo*, A. Gori*, Antonio Cassone*, and Claudio Piersimoni*
Table
Pattern of drug resistance among strains from tuberculosis patients with and without a history of treatment, Italy 1998–2001a
| Tested MTB strains | No history of previous treatment |
History of previous treatment |
||||
|---|---|---|---|---|---|---|
| No. | % | 95% CI | No. | % | 95% CI | |
| Total tested |
2,117 |
100 |
– |
322 |
100 |
– |
| Fully sensitive |
1,847 |
87.2 |
85.8 to 88.6 |
155 |
48.1 |
42.7 to 53.6 |
| Any drug |
270 |
12.7 |
11.4 to 14.2 |
167 |
51.8 |
46.4 to 57.3 |
| INH |
75 |
3.5 |
2.8 to 4.4 |
17 |
5.3 |
3.2 to 8.2 |
| RMP |
17 |
0.8 |
0.5 to 1.3 |
14 |
4.3 |
2.5 to 7.0 |
| EMB |
10 |
0.5 |
0.2 to 0.8 |
1 |
0.3 |
0.02 to 1.5 |
| SM |
93 |
4.3 |
3.6 to 5.3 |
14 |
4.3 |
2.5 to 7.0 |
| Resistant to both INH and RMP |
8 |
0.40 |
0.8 to 0.7 |
24 |
7.5 |
4.9 to 10.7 |
| Resistant to INH, RMP, EMB |
2 |
0.10 |
0.01 to 0.3 |
19 |
6.0 |
3.7 to 8.9 |
| Resistant to INH, RMP, SM |
6 |
0.30 |
0.1 to 0.6 |
23 |
7.1 |
4.7 to 10.4 |
| Resistant to INH, RMP, EMB, SM | 7 | 0.30 | 0.1 to 0.6 | 32 | 9.9 | 7.0 to 13.5 |
aMTB, Mycobacterium tuberculosis complex; CI, confidence interval; INH, isoniazid; RMP, rifampicin; EMB, ethambutol; SM, streptomycin.
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