TY - JOUR AU - Tambyah, Paul A. AU - Marx, John A. AU - Maki, Dennis G. T1 - Nosocomial Infection with Vancomycin-dependent Enterococci T2 - Emerging Infectious Disease journal PY - 2004 VL - 10 IS - 7 SP - 1277 SN - 1080-6059 AB - We report three patients infected with unique strains of vancomycin-dependent enterococci. Two were first infected by genetically identical strains of vancomycin-resistant enterococci (VRE). All three patients had much greater exposure to vancomycin and third-generation cephalosporins than did two control groups (patients infected with VRE and hospitalized patients without enterococcal infections). While antimicrobial pressure promotes nosocomial colonization by VRE, prolonged exposure to vancomycin may foster the transition from vancomycin resistance to dependence. KW - Vancomycin KW - antibiotic use KW - antimicrobial resistance KW - Enterococcus KW - nutritionally deficient microorganisms KW - vancomycin-resistant enterococci (VRE) KW - vancomycin-dependent enterococci (VDE) KW - dispatch KW - United States DO - 10.3201/eid1007.030993 UR - https://wwwnc.cdc.gov/eid/article/10/7/03-0993_article ER - End of Reference