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Volume 10, Number 9—September 2004
Research

Genetic Divergence and Dispersal of Yellow Fever Virus, Brazil

Pedro F.C. Vasconcelos*Comments to Author , Juliet E. Bryant†, Amelia P.A. Travassos da Rosa†, Robert B. Tesh†, Sueli G. Rodrigues*, and Alan D.T. Barrett†
Author affiliations: *World Health Organization Collaborating Center for Arbovirus Reference and Research, Instituto Evandro Chagas, Belém, Brazil; †University of Texas Medical Branch, Galveston, Texas, USA

Main Article

Table A1

Virus isolates used in this study

Isolate Strain ID Passage levela Sourceb Statec Community Biotoped/Climatee
JSS Brazil35 (38) Mosq1, SM8 Humanunk MT No data WC/EHW
Be H111 Brazil54 (39) c6/36, SM10 Human * PA Oriboca EA/EHW
BeAr 162 Brazil55B SM4, C6/36#1 Hg. janthinomys PA Pirelli Marituba EA/EHW
BeAr 189 Brazil55C (39) sm1 c6/36#1 Sabethes sp. PA Pirelli Marituba EA/EHW
BeAn 23536 Brazil602 SM1 c6/36#1 Cebus sp. PA Belém Brasília Km94 EA/EHW
BeAr 46299 Brazil62A (39) c6/36 Haemagogus sp. PA Belém Brasília Km94 EA/EHW
BeAr 44824 Brazil62B (39) SM1 c6/36#1 Haemagogus sp. PA Belém Brasília km87 EA/EHW
BeAn142028 Brazil68A2 c6/36#1 Saguinus sp. PA Abaetetuba EA/EHW
BeH141816 Brazil68B SM3, c6/36#1 Humanunk PA Abaetetuba EA/EHW
BeAr142658 Brazil68C (39) SM2, c6/36#1 Haemagogus sp. PA Barcarena EA/EHW
BeAn142027 Brazil68D (39) Original Saguinus midas PA Abaetetuba EA/EHW
BeH171995 Brazil69A SM1 c6/36#1 Human + PA Belém EA/EHW
BeH203410 Brazil71 (39) SM2, c6/36#1 Humanunk PA Peixe Boi EA/EHW
BeAr233164 Brazil73A (39) Mosq 4 Hg. janthinomys GO Goiás WC/TMW
BeAr232869 Brazil73B (39) Mosq 1, SM2 Haemagogus sp. GO Goiás WC/TMW
BeAr233436 Brazil73C (39) Original Haemagogus sp. GO Bela Vista WC/TMW
BeH233393 Brazil73D SM1 c6/36#1 Human+ GO Mara Rosa WC/TMW
BeH291597 Brazil75 SM2, Mosq 1 Human + MT Aripuanã WC/EHW
BeAr301129 Brazil76A SM1 c6/36#1 Haemagogus sp. PA Alenquer EA/EHW
BeH301035 Brazil76B SM1 c6/36#1 Human * PA Alenquer EA/EHW
BeH324213 Brazil77 SM1 c6/36#1 Human * PA Altamira EA/EHW
BeH350698 Brazil78A (38,39) SM2, Mosq 1 Human unk PA Tomé Acu EA/EHW
BeAr350397 Brazil78B SM2, Mosq 1 Haemagogus sp. PA Faz. Cangalha Formosa EA/EHW
BeH340824 Brazil78C SM1 c6/36#1 Human + PA Belterra-Santarém EA/EHW
BeH371220 Brazil79A SM1 c6/36#1 Human + PA Altamira EA/EHW
BeAr378600 Brazil80A SM2, C6/36#1 Haemagogus sp. GO Uruacu WC/TMW
BeH385780 Brazil80B (39) SM1 c6/36#1 Human + PA Altamira EA/EHW
BeH379501 Brazil80C SM2 Human + MA Montes Altos NEW/EHS
BeH394880 Brazil81 Original, C6/36#1 Human * PA Conceição Araguaia EA/EHW
BeH403366 Brazil82A SM1 c6/36#1 Human + MA Amarante do Maranhão NEW/EHS
BeH405954 Brazil82B SM1 c6/36#1 Human * PA Altamira EA/EHW
BeH 413820 Brazil83 SM1 c6/36#1 Human + RO Porto Velho WA/EHW
BeH425381 Brazil84A (39) c6/36 Human + AP Tribo Oyampi NA/EHW
BeAn 424208 Brazil84B Original, C6/36#1 Chiropotes satanas PA Tucuruí EA/EHW
BeAr424719 Brazil84C SM1 c6/36#1 Haemagogus sp. PA S. Domingos EA/EHW
BeAr424083 Brazil84D SM1 c6/36#1 Hg. albomaculatus PA Monte Alegre EA/EHW
BeAr424492 Brazil84E SM1 c6/36#1 Hg. janthinomys PA Faro EA/EHW
BeH422255 Brazil84F SM1 c6/36#1 Human + PA Faro EA/EHW
BeH423602 Brazil84G SM1 c6/36#1 Human + PA S. Domingos EA/EHW
BeH422312 Brazil84H SM1 Human + PA Monte Alegre EA/EHW
BeH436823 Brazil85A SM1 c6/36#1 Human + MT Sinop WC/EHW
BeAr437159 Brazil85B SM1 c6/36#1 Hg. janthinomys MT Sinop WC/EHW
BeH463676 Brazil87 SM1 c6/36#1 Human + PA Breves EA/EHW
BeH474245 Brazil88A SM1 c6/36#1 Human + GO Caiapônia WC/TMW
BeH474297 Brazil88B SM1 c6/36#1 Human + MG Paracatu SE/TSS
BeH485717 Brazil89 SM1 c6/36#1 Human + MG Francisco Dumont SE/TSS
BeAr 511437 Brazil91A2 SM1, C30c6/36#1 Hg. janthinomys PA Barcarena EA/EHW
BeH511843 Brazil91B SM1, C6/36#2 Human + RR Tribo Yanomamy WA/EHS
BeAn 510268 Brazil91C SM1 c6/36#1 Alouatta sp. GO Goiás WC/TMW
BeAr 512943 Brazil92A (39) SM1 C6/36-1 Vero2 Hg. janthinomys MS Sidrolândia WC/TMW
BeAr513008 Brazil92B (39) SM1 c6/36#1 Sabethes sp. MS Sidrolândia WC/TMW
BeH512772 Brazil92C (39) SM2, C6/36#1 Human unk MS Campo Grande WC/TMW
BeAr513060 Brazil92D SM1 c6/36#1 Haemagogus sp. MS Campo Grande WC/TMW
BeAr 513292 Brazil92E (39) SM1 C6/36-1 Vero1 Sabethes cloropterus MS Jaraguarí WC/TMW
BeH520988 Brazil93A SM1 c6/36#1 Human + MA Barra do Corda NEW/EHS
BeH521244 Brazil93B SM1 c6/36#1 Human * MA Mirador NEW/EHS
BeAr 527785 Brazil94A (39) SM1 c6/36#1 Sabethes cloropterus MG Arinos SE/TSS
BeAr527198 Brazil94B (39) SM1 c6/36#1 Haemagogus sp. MG Arinos SE/TSS
BeAr527547 Brazil94C SM2, vero1 Haemagogus sp. PA Don Eliseu EA/EHW
BeH526722 Brazil94D SM2, c6/36#1 Human + MG Arinos SE/TSS
BeAr528057 Brazil94E Original, C6/36#1 Hg. janthinomys MG Arinos SE/TSS
BeAr527410 Brazil94F Original, C6/36#1 Hg. janthinomys MA Pastos Bons NEW/EHS
BeH535010 Brazil95 SM2, c6/36#1 Human + MA Pastos Bons NEW/EHS
BeAr 544276 Brazil96A (39) SM1 c6/36#1 Hg. janthinomys RO Cabixi WA/EHW
BeAn 604552 Brazil98A Original, C6/36#1 Alouatta belzebul PA Afua NA/EHW
BeAr603401 Brazil98B Original, C6/36#1 Hg. janthinomys PA Altamira EA/EHW
BeAr605158 Brazil98C SM1 c6/36#1 Hg. janthinomys PA Afuá NA/EHW
BeH603325 Brazil98D Original, C6/36#1 Human unk PA Afuá EA/EHW
BeH605427 Brazil98E SM1 c6/36#1 Human + PA Carajas EA/EHW
BeAr614320 Brazil99B SM2 Haemagogus sp. PA Breves NA/EHW
BeAr617127 Brazil99D SM1 c6/36#1 Hg. janthinomys TO Monte do Carmo EA/EHS
BeH613582 Brazil99E SM1 c6/36#1 Human * PA Breves NA/EHW
BeAr628124 Brazil00A (39) SM1 c6/36#1 Hg. janthinomys TO Paranã EA/EHS
BeH 622491 Brazil00B SM1 Human + DF Brasilia WC/THA
BeAn625923 Brazil00C Original, C6/36#1 Alouatta sp. GO Goiás WC/TMW
BeH 622205 Brazil0D SM1 c6/36#1 Human * GO Goiás WC/TMW
BeAr630768 Brazil01A SM1 Hg. janthinomys GO Alto Paraiso WC/TMW
BeAr631464 Brazil01B SM1 c6/36#1 Sa. chloropterus BA Jaborandi NED/THA
BeAr645693 Brazil01D SM1 c6/36#1 Haemagogus MG Uberaba SE/TSS

aPassage history of seed strain in collection. SM, suckling mouse.
bOutcome of human cases, unk = unknown, + = fatal, * = recovered.
cAP, Amapa; BA, Bahia; DF, Federal District; GO, Goiás; MA, Maranhão; MG, Minas Gerais; MS, Mato Grosso do Sul; MT, Mato Grosso; PA, Pará; RO, Rondônia; RR, Roraima; TO, Tocantins.
dEA, East Amazon; NA, Northern Amazon; NED, Northeast Dry; NEW, Northeast Wet; S, South; SE, Southeast; WA, West Amazon; WC, West-Central.
eEHW, equatorial, hot and wet; EHS, equatorial, hot and semi-wet; THA, tropical, hot and semi-arid; THW, tropical, semi-hot and wet; TMW, tropical, mesothermal, wet; TSW, tropical, semi-hot, wet; TSS, tropical, semi-hot and semi-wet.

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References
  1. Monath  TP. Epidemiology of yellow fever: current status and speculations on future trends. In: Saluzzo JF, Dodet B, editors. Amsterdam: Elsevier; 1997. p. 143–65.
  2. Robertson  SE, Hull  BP, Tomori  O, Bele  O, LeDuc  JW, Esteves  K. Yellow fever: a decade of reemergence. JAMA. 1996;276:115762. DOIPubMedGoogle Scholar
  3. Vainio  J, Cutts  F. Yellow fever. Global programme for vaccines and immunization. WHO/EPI/GEN/98.11. Geneva: World Health Organization; 1998.
  4. Vasconcelos  PFC, Costa  ZG, Travassos da Rosa  ES, Luna  E, Rodrigues  SG, Barros  VLRS, Epidemic of jungle yellow fever in Brazil, 2000: implications of climatic alterations in disease spread. J Med Virol. 2001;65:598604. DOIPubMedGoogle Scholar
  5. Filippis  AM, Schatzmayr  HG, Nicolai  C, Baran  M, Miagostovich  MP, Sequeira  PC, Jungle yellow fever, Rio de Janeiro. Emerg Infect Dis. 2001;7:4845.PubMedGoogle Scholar
  6. Dégallier  N, Travassos da Rosa  AP, Hervé  JP, Travassos da Rosa  JFS, Vasconcelos  PFC, Silva  CJM, A comparative study of yellow fever in Africa and South America. J Braz Assoc Advanc Sci. 1992;44:14351.
  7. Mondet  B, Travassos da Rosa  APA, Vasconcelos  PFC. The risk of urban yellow fever outbreaks in Brazil by dengue vectors Aedes aegypti and Aedes albopictus. Bull Soc Pathol Exot. 1996;89:10713.PubMedGoogle Scholar
  8. Fundação Nacional de Saúde (FUNASA). Distribuição de casos confirmados de febre amarela notificados por unidade federativa no Brasil, 1981–2002. Brasília: Ministério da Saúde; 2003.
  9. Massad  E, Burattini  MN, Coutinho  FA, Lopez  LF. Dengue and the risk of urban yellow fever reintroduction in Sao Paulo State, Brazil. Rev Saude Publica. 2003;37:47784. DOIPubMedGoogle Scholar
  10. Figueiredo  LT. The Brazilian flaviviruses. Microbes Infect. 2000;2:16439. DOIPubMedGoogle Scholar
  11. Beaty  BJ, Calisher  CH, Shope  RE. Arboviruses. In: Lennette EH, Schmidt NJ, editors. Diagnostic procedures for viral, rickettsial, and chlamydial infections. 6th ed. Washington: American Public Health Association; 1989. p. 797–855.
  12. Kuno  G, Chang  GJ, Tsuchiya  KR, Karabatsos  N, Cropp  CB. Phylogeny of the genus Flavivirus. J Virol. 1998;72:7383.PubMedGoogle Scholar
  13. Wang  E, Weaver  SC, Shope  RE, Tesh  RB, Watts  DM, Barrett  AD. Genetic variation in yellow fever virus: duplication in the 3´ noncoding region of strains from Africa. Virology. 1996;225:27481. DOIPubMedGoogle Scholar
  14. Bryant  JE, Barrett  ADT. Comparative phylogenies of yellow fever isolates from Peru and Brazil. FEMS Immunol Med Microbiol. 2003;39:10318. DOIPubMedGoogle Scholar
  15. Deubel  V, Digoutte  JP, Monath  TP, Girard  M. Genetic heterogeneity of yellow fever virus strains from Africa and the Americas. J Gen Virol. 1986;67:20913. DOIPubMedGoogle Scholar
  16. Swofford  DL. PAUP*. Phylogenetic analysis using parsimony (* and other methods). Sunderland (MA): Sinauer Associates; 1998.
  17. Hahn  CS, Dalrymple  JM, Strauss  JH, Rice  CM. Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it. Proc Natl Acad Sci U S A. 1987;84:201923. DOIPubMedGoogle Scholar
  18. Duarte dos Santos  CN, Post  PR, Carvalho  R, Ferreira  II, Rice  CM, Galler  R. Complete nucleotide sequence of yellow fever virus vaccine strains 17DD and 17D-213. Virus Res. 1995;35:3541. DOIPubMedGoogle Scholar
  19. Vasconcelos  PFC, Luna  EJ, Galler  R, Silva  LJ, Coimbra  TL, Barros  VLRS, Serious adverse events associated with yellow fever 17DD vaccine in Brazil: a report of two cases [errata in Lancet. 2001;358:336; Lancet. 2001;358:1018]. Lancet. 2001;358:917. DOIPubMedGoogle Scholar
  20. Mutebi  JP, Wang  H, Li  L, Bryant  JE, Barrett  AD. Phylogenetic and evolutionary relationships among yellow fever virus isolates in Africa. J Virol. 2001;75:69997008. DOIPubMedGoogle Scholar
  21. Rey  FA, Heinz  FX, Mandl  C, Kunz  C, Harrison  SC. The envelope glycoprotein from tick-borne encephalitis virus at 2 angstrom resolution. Nature. 1995;375:2918. DOIPubMedGoogle Scholar
  22. Allison  SL, Schalich  J, Stiasny  K, Mandl  CW, Heinz  FX. Mutational evidence for an internal fusion peptide in flavivirus envelope protein E. J Virol. 2001;75:426875. DOIPubMedGoogle Scholar
  23. Fitzgeorge  R, Bradish  CJ. The in vitro differentiation of strains of yellow fever virus in mice. J Gen Virol. 1980;46:113. DOIPubMedGoogle Scholar
  24. Monath  TP. Milestones in the conquest of yellow fever. In: Koprowski H, Oldstone MBA, editors. Microbes and man—then and now. Bloomington (IN): Medi-Ed Press; 1996. p. 95–111.
  25. Heraud  JM, Hommel  D, Hulin  A, Deubel  V, Poveda  JD, Sarthon  JL, First case of yellow fever in French Guiana since 1902. Emerg Infect Dis. 1999;5:42932. DOIPubMedGoogle Scholar
  26. Soper  FL. Ventures in world health. Scientific publication no. 355. Washington: Pan American Health Organization; 1977.
  27. Monath  TP. Yellow fever: Victor, Victoria? Conqueror, conquest? Epidemics and research in the last 40 years and prospects for the future. Am J Trop Med Hyg. 1991;45:143.PubMedGoogle Scholar
  28. Pinheiro  FP, Travassos da Rosa  APA, Moraes  MAP, Almeida Neto  JC, Camargo  S, Filgueiras  JP. An epidemic of yellow fever in central Brazil, 1972–1973. I. Epidemiological studies. Am J Trop Med Hyg. 1978;27:12532.PubMedGoogle Scholar
  29. Chippaux  A, Deubel  V, Moreau  JP, Reynes  JM. Current situation of yellow fever in Latin America. Bull Soc Pathol Exot. 1993;86:4604.PubMedGoogle Scholar
  30. Kiple  KF, Cooper  DB. Yellow fever. In: Kiple KF, Graham RR, editors. Cambridge: Cambridge University Press; 1993. p. 1100–7.
  31. Monath  TP. Yellow fever. In: Monath TP, editor. The arboviruses—epidemiology and ecology. Vol. 5. Boca Raton (FL): CRC Press; 1989. p. 139–231.
  32. Vasconcelos  PFC, Travassos da Rosa  APA, Pinheiro  FP, Rodrigues  SG, Travassos da Rosa  ES, Cruz  ACR, Aedes aegypti, dengue, and re-urbanization of yellow fever in Brazil and other South American countries: past and present situation and future perspectives. Dengue Bull. 1999;23:5566.
  33. Vasconcelos  PFC, Rodrigues  SG, Dégallier  N, Moraes  MAP, Travassos da Rosa  JFS, Travassos da Rosa  ES, Epidemic of sylvatic yellow fever in southeast region of Maranhão State, Brazil, 1993–1994. Epidemiological and entomological findings. Am J Trop Med Hyg. 1997;57:1327.PubMedGoogle Scholar
  34. Vasconcelos  PFC, Travassos da Rosa  APA, Rodrigues  SG, Travassos da Rosa  ES, Montiero  HÃO, Cruz  ACR, Yellow fever in Pará State, Amazon region of Brazil, 1998–1999. Entomological and epidemiological findings. Emerg Infect Dis. 2001;7:5659. DOIPubMedGoogle Scholar
  35. Saeed  MF, Wang  H, Nunes  M, Vasconcelos  PFC, Weaver  SC, Shope  RE, Nucleotide sequences and phylogeny of the nucleocapsid gene of Oropouche virus. J Gen Virol. 2000;81:7438.PubMedGoogle Scholar
  36. Chan  RC, Penney  DJ, Little  D, Carter  IW, Roberts  JA, Rawlinson  WD. Hepatitis and death following vaccination with 17D-204 yellow fever vaccine. Lancet. 2001;358:1212. DOIPubMedGoogle Scholar
  37. Martin  M, Tsai  TF, Cropp  B, Chang  GJJ, Holmes  DA, Tseng  J, Fever and multisystem organ failure associated with 17D-204 yellow fever vaccination: a report of four cases. Lancet. 2001;358:98104. DOIPubMedGoogle Scholar
  38. Wang  E, Weaver  SC, Shope  RE, Tesh  RB, Watts  DM, Barrett  AD. Genetic variation in yellow fever virus: duplication in the 3´noncoding region of strains from Africa. Virology. 1996;225:27481. DOIPubMedGoogle Scholar
  39. Bryant  JE, Barrett  ADT. Comparative phylogenies of yellow fever isolates from Peru and Brazil. FEMS Immunol Med Microbiol.

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