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Volume 11, Number 1—January 2005

Distribution and Characteristics of Escherichia coli Clonal Group A1

James R. Johnson*†Comments to Author , Andrew C. Murray*†, Michael A. Kuskowski*†, Sören Schubert‡, Marie-Francoise Prère§, Bertrand Picard¶, Raul Colodner#, Raul Raz#**, and TIARAInvestigators
Author affiliations: *VA Medical Center, Minneapolis, Minnesota, USA; †University of Minnesota, Minneapolis, Minnesota, USA; ‡Max von Pettenkofer-Institut für Hygiene und Medizinische Mikrobiologie, München, Germany; §Centre Hospitalier Universitaire Purpan, Toulouse, France; ¶Hôpital Morvan, Brest, France; #HaEmek Medical Center, Afula, Israel; **Technion School of Medicine, Afula, Israel

Main Article

Table 1

Sources of Escherichia coli clinical isolates and local prevalence of E. coli clonal group A (CGA) by trimethoprim-sulfamethoxazole (TMP-SMZ) phenotype*

Location Type of institution Patient population Specimen type(s) I/P or O/P† Local 
TMP-SMZ resistance 
rate (%) Total no. isolates Prevalence of CGA, proportion (%)‡
p value
TMP-SMZ–susceptible TMP-SMZ–resistant
Curitiba, Brazil University medical center Mostly adults Urine Unknown 33 60 1/30 (3) 2/30 (7)
Montreal, Canada University medical center Mostly adults Urine, other I/P, O/P 33 50 0/25 (0) 0/25 (0)
London, England Teaching hospital Mostly adults Urine Unknown 29 46 n.a. 0/46 (0)
Brest, France University medical center Mostly adults Urine, blood I/P, O/P 30 59 0/29 (0) 0/30 (0)
Toulouse, France Children’s hospital Children Urine, other I/P, O/P 24 50 0/25 (0) 5/25 (20) 0.05
Münich, Germany
University medical center
Mostly adults
0/27 (0)
2/28 (14)

Afula, Israel Outpatient clinic Women Urine O/P 30 100 1/51 (2) 3/49 (6)
Barcelona, Spain Private medical center Mostly adults Urine, other I/P, O/P 37 74 2/30 (7) 0/44 (0)
Göteborg, Sweden University medical center Mostly adults Unknown Unknown 10% 48 0/25 (0) 1/23 (4)
Bangkok, Thailand Government hospital Adults Urine, other I/P, O/P 67 48 0/24 (0) 1/24 (4)
Baltimore, MD, USA Student health center Mostly women Urine O/P 29 62 2/24 (8) 7/38 (18)
Billings, MT, USA
Private medical center
Mostly adults
Urine, other
I/P, O/P
0/25 (0)
3/25 (12)

Birmingham, AL, USA University medical center Mostly adults Urine, other I/P, O/P 18 48 1/23 (4) 1/25 (4)
Chicago, IL, USA County medical center Mostly adults Urine O/P 24 24 NA 7/24 (29)
Columbus, OH, USA University medical center Children Urine I/P, O/P 13 59 0/33 (0) 6/26 (23) 0.005
Iowa City, IA, USA (Multiple) Unknown Urine, other Unknown 18 58 0/27 (0) 4/31 (13)
Houston, TX, USA
Children’s medical center
Urine, other
I/P, O/P
1/32 (3)
7/28 (25)
Rochester, MN, USA Private medical center Mostly adults Urine, other I/P, O/P 16 54 1/28 (4) 0/26 (0)
Seattle, WA, USA Teaching hospital Adults Unknown Unknown 15 50 0/24 (0) 6/26 (23) 0.02
Tucson, AZ, USA Veterans medical center Men Unknown Unknown 25 47 0/34 (0) 2/13 (15)

*Isolates were collected in 2001 for all sites except London, England (1999), and Columbus, Ohio (1999 for susceptible isolates and part of resistant isolates; 2002 for remaining resistant isolates).
†I/P, inpatient; O/P, outpatient.
‡Eighteen centers contributed both susceptible and resistant isolates (total, 47 to 100 isolates each; median, 55). Two centers contributed only resistant isolates (Chicago, IL: 24 isolates; England: 46 isolates). Specimen type was known for 55 of the CGA isolates and was urine for 42, nonurine for 13 (10 blood, 1 tracheal aspirate, 1 fecal, 1 unspecified nonurine).

Main Article

1Presented at the American Society for Microbiology 103rd General Meeting, May 18–22, 2003, Washington, D.C.

2The TIARA investigators include the following: Sacared Bodison (University of Maryland, College Park, MD), Franklin R. Cockerill, III (Mayo Clinic and Mayo Medical School, Rochester, MN), Clovis Arns da Cunha (Curitiba-PR, Brazil), Peter Echeverria and Sriluck Simasathien (Armed Forces Research Institute of Medical Sciences and Phramonkutkho Army Hospital, Bangkok, Thailand), Wim Gaastra (University of Utrecht, Utrecht, The Netherlands), Lucinda M.C. Hall (St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK), Marina Klein (McGill University Health Centre, Montreal, Quebec, Canada), Hank A. Lockman (Battelle Memorial Institute, Columbus, OH), Imad Omer and Jane R. Schwebke (University of Alabama, Birmingham, AL), Guillem Prats (Hospital Vall d'Hebron, Barcelona, Spain), Robert M. Rakita (Virginia Mason Medical Center, Seattle, WA), Susan Rossman (Texas Childrens Hospital, Houston, TX), Ronald Schiffman (Southern Arizona VA Medical Center, Tucson, AZ), Ronald Smith (Billings Clinic and Providence Medical Center, Billings, MT), and Patricia L. Winokur (VA Medical Center and University of Iowa, Iowa City, IA).

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