TY - JOUR AU - Grainge, Matthew AU - Seth, Rashmi AU - Guo, Li AU - Neal, Keith AU - Coupland, Carol AU - Vryenhoef, Paul AU - Johnson, Jane AU - Jenkins, David T1 - Cervical Human Papillomavirus Screening among Older Women T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 11 SP - 1680 SN - 1080-6059 AB - Rates of acquisition and clearance of cervical human papillomavirus (HPV) during a 3-year period in women 51 years of age were compared with rates in younger women to provide data on cervical screening for women >50 years of age. Paired, cytologically negative, archived cervical smears taken 3 years apart from 710 women in Nottingham, United Kingdom, were retrieved and tested for HPV infection with polymerase chain reaction (PCR) with GP5+/6+ primers. Seventy-one (21.3%) of 333 women 51 years of age who were HPV negative at baseline were positive 3 years later. This percentage was higher than the corresponding acquisition rates among women 21 (15.2%), 31 (14.1%), and 41 (13.3%) years of age, although these differences were not significant. This retrospective study shows that HPV-negative women >50 years of age can acquire HPV and, therefore, require cervical screening. KW - human papillomavirus KW - cervix neoplasms KW - incidence KW - natural history KW - age factors KW - epidemiologic studies KW - retrospective studies KW - research KW - United Kingdom DO - 10.3201/eid1111.050575 UR - https://wwwnc.cdc.gov/eid/article/11/11/05-0575_article ER - End of Reference