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Volume 11, Number 12—December 2005
Research

SARS-CoV Infection in a Restaurant from Palm Civet

Ming Wang*1, Meiying Yan†‡1, Huifang Xu*1, Weili Liang†‡1, Biao Kan†‡1, Bojian Zheng§1, Honglin Chen§1, Han Zheng†‡, Yanmei Xu†‡, Enmin Zhang†‡, Hongxia Wang†‡, Jingrong Ye†‡, Guichang Li†, Machao Li†, Zhigang Cui†‡, Yu-Fei Liu*, Rong-Tong Guo*, Xiao-Ning Liu*, Liu-Hua Zhan*, Duan-Hua Zhou*, Ailan Zhao†‡, Rong Hai†‡, Dongzhen Yu†‡, Yi Guan§, and Jianguo Xu†‡Comments to Author 
Author affiliations: *Guangzhou Municipal Center for Disease Control and Prevention, Guangdong, People's Republic of China; †National Institute for Communicable Disease Control and Prevention, Beijing, People's Republic of China; ‡State Key Laboratory of Infectious Diseases Prevention and Control, Bejing, People's Republic of China; §University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China

Main Article

Table 2

Comparison of signature nucleotide variations in the spike (S) gene of SARS-CoV from various sources*

Virus Source Signature nucleotide variation position of S gene†
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 4 4 5
9 5 5 5 8 8 9 9 9 9 9 3 3 3 4 7 7 8 5 9 0
0 1 2 7 7 7 0 2 2 3 5 1 1 3 8 1 8 2 6 7 3
7 7 2 0 4 5 6 7 8 0 1 6 7 0 5 9 5 3 6 8 1
Civet007 Civet, restaurant T G G C T T C G A G G T T A C G T G C G C
Civet010 Civet, restaurant T G G C T T C G A G G T T A C G T G C G C
Civet019 Civet, restaurant T G G C T T C G A G G T T A C G T G C G C
Civet020 Civet, restaurant T G G C T C C G A G G T T A C G T G C G C
Civet014 Civet, restaurant T G G C T C C A A G G T T A C G T G C G C
Waitress Patient 2, waitress G A G G
Customer Patient 4, customer G A G G
GD03T0013 Patient 1 T G G C T C C A T G G T T A C G T G C G C
SZ3 Civet, market C G G C C C T A A A G G C T C C C G C G T
SZ16 Civet, market C G G C C C T A A A G G C T C C C G C G T
GZ60 Early phase C G G T C C T A T A C G C T C C C G T A T
HGZ8L1-A Early phase C G G T C C T A T A C G C T T C C G T A T
ZS-A Early phase C G G T C C T A T A C G C T T C C G T A T
ZS-B Early phase C G G T C C T A T A C G C T T C C G T A T
ZS-C Early phase C G G T C C T A T A C G C T T C C G T A T
GD01 Early phase C G G T C C T A T A C G C T T C C G C A T
GZ02 Early phase C G G T C C T A T A C G C T T C C G T G T
HSZ-Bb Early phase C A A T C C T A T A C G C T T C C G T G T
HSZ-Bc Early phase C A A T C C T A T A C G C T T C C G T G T
HSZ-Cb Early phase C A A T C C T A T A C G C T T C C G T G T
HSZ-Cc Early phase C A A T C C T A T A C G C T T C C G T G T
GZ50 Middle phase C A A T C C T A T A C G C T T C C T T A T
BJ01 Late phase C A A T C C T A T A C G C T T C C T T A T
BJ03 Late phase C A A T C C T A T A C G C T T C C T T A T
HKU-36871 Late phase C A A T C C T A T A C G C T T C C T T A T
HKU-39849 Late phase C A A T C C T A T A C G C T T C C T T A T
HKU-65806 Late phase C A A T C C T A T A C G C T T C C T T A T
CUHK-W1 Late phase C A A T C C T A T A C G C T T C C T T A T
CUHK-Su10 Late phase C A A T C C T A T A C G C T T C C T T A T
Fra Late phase C A A T C C T A T A C G C T T C C T T A T
Tor2 Late phase C A A T C C T A T A C G C T T C C T T A T
Urbani Late phase C A A T C C T A T A C G C T T C C T T A T

*Blank spaces indiate information not available. Early, middle, and late phases indicate when virus was isolated from patients in various stages of the 2003 epidemic. SARS-CoV, severe acute respiratory syndrome.

†Numbers indicate position of signature nucleotide variations on the virus genome based on SARS-CoV Tor2 numbering. The 4 signature nucleotide variations in 286-bp S gene sequences for isolates from 2 restaurant-related patients were identical to 4 of 5 S gene sequences of palm civets at the restaurant.

Main Article

1These authors contributed equally to this article.

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