TY - JOUR AU - Oteo, Jesús AU - Lázaro, Edurne AU - de Abajo, Francisco J. AU - Baquero, Fernando AU - Campos, José T1 - Antimicrobial-resistant Invasive Escherichia coli, Spain T2 - Emerging Infectious Disease journal PY - 2005 VL - 11 IS - 4 SP - 546 SN - 1080-6059 AB - To address the public health problem of antimicrobial resistance, the European Union founded the European Antimicrobial Resistance Surveillance System. A network of 32 Spanish hospitals, serving ≈9.6 million persons, submitted antimicrobial-susceptibility data on 7,098 invasive Escherichia coli species (2001–2003). Resistance to ampicillin, cotrimoxazole, ciprofloxacin, gentamicin, and tobramycin was found at rates of 59.9%, 32.6%, 19.3%, 6.8%, and 5.3%, respectively. Resistance to multiple drugs increased from 13.8% in 2001 to 20.6% in 2003 (p < 0.0001). Antimicrobial consumption data were obtained from the Spanish National Health System. In spite of decreased cephalosporin and β-lactam use, overall extended-spectrum β-lactamase production increased from 1.6% (2001) to 4.1% (2003) (p < 0.0001), mainly due to the rising prevalence of cefotaximases. Resistance to ciprofloxacin significantly increased, mostly in community-onset infections, which coincided with a rise in community quinolone use. Cotrimoxazole resistance remained stable at ≈30%, even though its use was dramatically reduced. KW - invasive pathogens KW - Escherichia coli KW - antimicrobial susceptibility KW - Spain KW - research DO - 10.3201/eid1104.040699 UR - https://wwwnc.cdc.gov/eid/article/11/4/04-0699_article ER - End of Reference