TY - JOUR AU - Palese, Peter T1 - Making Better Influenza Virus Vaccines? T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 1 SP - 61 SN - 1080-6059 AB - Killed and live influenza virus vaccines are effective in preventing and curbing the spread of disease, but new technologies such as reverse genetics could be used to improve them and to shorten the lengthy process of preparing vaccine seed viruses. By taking advantage of these new technologies, we could develop live vaccines that would be safe, cross-protective against variant strains, and require less virus per dose than conventional vaccines. Furthermore, pandemic vaccines against highly virulent strains such as the H5N1 virus can only be generated by reverse genetics techniques. Other technologic breakthroughs should result in effective adjuvants for use with killed and live vaccines, increasing the number of available doses. Finally, universal influenza virus vaccines seem to be within reach. These new strategies will be successful if they are supported by regulatory agencies and if a robust market for influenza virus vaccines against interpandemic and pandemic threats is made and sustained. KW - Influenza virus KW - Live vaccine KW - Killed vaccine KW - Reverse genetics KW - Cold-adapted vaccine. Universal vaccine KW - Adjuvant KW - Interferon KW - NS1 vaccine KW - Recombinant virus KW - Perspective DO - 10.3201/eid1201.051043 UR - https://wwwnc.cdc.gov/eid/article/12/1/05-1043_article ER - End of Reference