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Volume 12, Number 10—October 2006
Research

Active Cytomegalovirus Infection in Patients with Septic Shock

Lutz von Müller*, Anke Klemm*, Manfred Weiss*, Marion Schneider*, Heide Suger-Wiedeck*, Nilgün Durmus*, Walter Hampl*, and Thomas Mertens*Comments to Author 
Author affiliations: *University Hospital Ulm, Ulm, Germany

Main Article

Table

Characteristics and clinical course of patients with septic shock, with and without active CMV infection*

Active CMV infection No active CMV infection Significance
No. patients 8 17
CMV IgG, index 12.4 (5.4–14.7) 11.7 (1.5–18.3) NS†
CMV IgM, index 0.4 (0.28–3.94) 0.28 (0.2–1.8) NS†
Sex, n
Male 5 10 NS‡
Female 3 7 NS‡
Age, y 66 (40–78) 60 (44–78) NS†
Primary condition, n
Abdominal surgery 1 7 NS‡
Abdominal tumor 1 4 NS‡
Pancreatitis 3 1 NS‡
Trauma 2 5 NS‡
Vascular surgery 1 0 NS‡
Bacteremia, n (%) 4 (50) 10 (59) NS‡
Candidemia, n (%) 2 (25) 1 (6) NS‡
SOFA score§ 10 (7–13) 10 (7–16) NS‡
Leukocyte count, g/L§ 27 (10.4–53.3) 22.4 (7.2–74.3) NS†
Platelet count, g/L¶ 106 (37–151) 112 (37–385) NS†
Serum creatinine, μmol/L§ 183 (73–345) 160 (72–347) NS†
Serum bilirubin, μmol/L§ 27 (6–279) 54 (4–336) NS†
Aspartate aminotransferase, U/L§ 55 (7–267) 45 (9–229) NS†
C-reactive protein, mg/L§ 258 (16–456) 220 (115–437) NS†
ICU stay after onset of septic shock, d 42 (16–87) 18 (10–42) p = 0.0025†
Mechanical ventilation, d 39 (15–80) 16 (5–38) p = 0.0025†
Receipt of catecholamines, d 7 (4–41) 7 (1–35) NS†
Mortality rate, n (%) 5 (63) 6 (35) NS‡
HSV reactivation, n (%) 6 (75) 2 (12) p = 0.0036‡

*Median (range), unless otherwise indicated; CMV, cytomegalovirus; Ig, immunoglobulin; NS, not significant (p>0.05); SOFA, sepsis-related organ failure assessment; ICU, intensive care unit; HSV, herpes simplex virus.
†According to Mann-Whitney U test.
‡According to Fisher exact test.
§Highest values.
¶Lowest values.

Main Article

Page created: November 10, 2011
Page updated: November 10, 2011
Page reviewed: November 10, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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