Volume 12, Number 11—November 2006
Letter
Resistance to Dihydroartemisinin
Table
Polymorphism in PfATPase6 and G7 genes and in vitro susceptibility to dihydroartemisinin of 154 Plasmodium falciparum isolates*
Gene | Predicted products | Position | Amino acid | Nucleotide change | No. isolates | Dihydroartemisinin IC50 (nmol/L) |
---|---|---|---|---|---|---|
ATPase6 | Sarcoplasmic reticulum calcium- transporting ATPases | 769 | S | AGT | 153 | 0.1–31.8 |
S→N | AAT | 1 | 0.83 | |||
263 | L | TTA | 154 | 0.1–31.8 | ||
L→S | TCA | 0 | ||||
243 | H | CAT | 152 | 0.1–31.8 | ||
H→Y | TAT | 2 | 4.2; 6.4 | |||
G7 | ABC transporter | 1,390 | Wild | (AAT)4 | 69 | 0.1–25.9 |
Mutant (3-bp indel) | (AAT)3 | 85 | 0.15–31.8
*PfATPase, Plasmodium falciparum adenosine triphosphatase; IC50, 50% inhibitory concentration. |
*PfATPase, Plasmodium falciparum adenosine triphosphatase; IC50, 50% inhibitory concentration.