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Volume 12, Number 12—December 2006
Perspective

On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease

Paul Brown*Comments to Author , Lisa M. McShane†, Gianluigi Zanusso‡, and Linda Detwiler§
Author affiliations: *Bethesda, Maryland, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡University of Verona, Verona, Italy,; §Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA

Main Article

Table 2

Summary of atypical cases of bovine spongiform encephalopathy (BSE)

Country Age, y Breed Symptoms Neuropathology
Western blot pattern*
Spongiform changes Immunohistochemistry
Italy 11 Bruna Alpina None Mild Plaques L
15 Piemontese None Mild Plaques L
Denmark 14 Charolais None NR NR L
Poland 12 Black-white breed None Present Positive (no plaques) L
Japan 2 Holstein None Absent Negative L1
14 Japanese Black Dystasia Severe Positive (no plaques) H
Belgium 5.5 East-Flemish None Absent Negative L1
France 10 Cross breed None NR NR H
15 Prim Holstein None NR NR H
8 Charolais None NR NR H
The Netherlands 13 Black-white Holstein, Freisian NR Present No plaques H
Sweden 12 Mixed Charolais Recumbent NR Positive (no plaques) H1
Switzerland 19 Zebu Typical BSE Typical BSE Positive (no plaques) H
Germany 13 Angus NR Absent Positive (no plaques) H
15 Holstein-Freisian NR Absent Positive (no plaques) L
USA 12 Brahma cross Falling Absent No plaques H
10 Red crossbred Recumbent Absent No plaques H
Canada 16 Charolais Recumbent NR Positive (no plaques) H

*L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland.

*L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland.

*L, lower molecular weight; H, higher molecular weight (the 2 major Western blot PrP glycopatterns that distinguish the strains from each other and from the pattern seen in typical BSE); NR, not reported. Only the Italian cows and Swiss zebu had full neuropathologic examinations (others were limited to examination of the obex). Details are not available for additional animals with both H and L strains in France and Poland.

Main Article

Page created: October 04, 2011
Page updated: October 04, 2011
Page reviewed: October 04, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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