Volume 12, Number 3—March 2006
Cost-effectiveness of West Nile Virus Vaccination
|Variable||Lower limit||Baseline||Upper limit|
|Probability of infection||0.012||0.016||0.02|
|Probability of symptomatic illness||0.15||0.20||0.25|
|Probability of symptomatic illness after vaccination†||0.03||0.04||0.05|
|Probability of neuroinvasive disease, given symptoms||0.027||0.036||0.045|
|Probability of death, given neuroinvasive disease||0.07||0.09||0.11|
|Probability of disability, given neuroinvasive disease||0.26||0.35||0.44|
|Cost of neuroinvasive disease||$20,625||$27,500||$34,375|
|Cost of death (direct and indirect financial losses)||$150,000||$200,000||$250,000|
|Cost of lifelong disability||$158,000||$210,000||$263,000|
|Cost of uncomplicated WNV febrile illness||$750||$1,000||$1,250|
|Cost of vaccination||$75||$100||$125|
*Upper and lower limits are calculated as ±25% of the baseline values and rounded up.
†Baseline vaccine effectiveness is assumed to be 80%.
Page created: January 27, 2012
Page updated: January 27, 2012
Page reviewed: January 27, 2012
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