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Volume 12, Number 4—April 2006
Research

Contrasting Pediatric and Adult Methicillin-resistant Staphylococcus aureus Isolates

Michael Z. David*Comments to Author , Susan E. Crawford*, Susan Boyle-Vavra*, Mark A. Hostetler*, Daniel C. Kim*, and Robert S. Daum*
Author affiliations: *University of Chicago, Chicago, Illinois, USA

Main Article

Table 2

Percentage of methicillin-resistant Staphylococcus aureus isolates resistant to non–β-lactam antimicrobial drugs among pediatric and adult patients, stratified by hospital- and community-associated designation

Antimicrobial drug Adult outpatient isolates (n = 105) Pediatric outpatient isolates (n = 115) p value*
Ciprofloxacin 55.2 9.6 <0.001
Clindamycin
Resistant† 37.1 6.1 <0.001
D-test positive‡ 20.4 14.8 0.39
Erythromycin 91.4 88.7 0.16
Gentamicin 8.6 1.7 0.03
Rifampin 1.9 0 0.23
Tetracycline§ 13.3 3.6 0.01
TMP-SMX¶ 0 0 NA
Vancomycin 0 0 NA

*p value compares resistance to indicated antimicrobial drugs or positive test result among adult vs. pediatric isolates by χ2 test or Fisher exact test. NA, not applicable.
†Figures in this row represent Vitek testing results for clindamycin.
‡54 (97.1%) and 88 (93.9%) of the adult and pediatric isolates, respectively, that were erythromycin resistant and clindamycin susceptible by Vitek were evaluated by D-testing.
§Tetracycline susceptibility was not tested for 5 pediatric outpatient isolates and 2 adult outpatient isolates.
¶TMP-SMX, trimethoprim-sulfamethoxazole. Only 42 adult and 27 pediatric isolates that were erythromycin resistant and clindamycin susceptible were tested.

Main Article

Page created: January 24, 2012
Page updated: January 24, 2012
Page reviewed: January 24, 2012
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