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Volume 12, Number 8—August 2006
Synopsis

Invasive Enterobacter sakazakii Disease in Infants

Anna Bowen*Comments to Author  and Christopher R. Braden*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table 1

Cases of invasive Enterobacter sakazakii disease among infants

Year of report Location No. cases Reference
1961 England 2 (15)
1965 Denmark 1 (5)
1979 Georgia, USA 1 (7)
1981 Indiana, USA 1 (16)
Oklahoma, USA 1
1983 Netherlands 8 (8)
1985 Missouri, USA 1 (17)
1988 USA 2
1989 Portugal 1 (18)
Iceland 3 (3)
Tennessee, USA 3 (10)
1990 Maryland, USA 1 (19)
1991 Ohio, USA 1 (20)
2000 North Carolina, USA 1
2001 Israel 2 (2,4)
Belgium 1 (9)
2002 Israel 2 (4)
Tennessee, USA 1 (1)
Wisconsin, USA 1 CDC, unpub. data
2003 USA 6 CDC, unpub. data
2004 France 2 (14)
USA 2 CDC, unpub. data
2005 USA 2 CDC, unpub. data

Main Article

References
  1. Centers for Disease Control and Prevention. Enterobacter sakazakii infections associated with the use of powdered infant formula—Tennessee, 2001. MMWR Morb Mortal Wkly Rep. 2002;51:297–300.PubMedGoogle Scholar
  2. Bar-Oz  B, Peleg  O, Block  C, Arad  I. Enterobacter sakazakii infection in the newborn. Acta Paediatr. 2001;90:356–8. DOIPubMedGoogle Scholar
  3. Biering  G, Karlsson  S, Clark  N, Jonsdottir  K, Ludvigsson  P, Steingrimsson  O. Three cases of neonatal meningitis caused by Enterobacter sakazakii in powdered milk. J Clin Microbiol. 1989;27:2054–6.PubMedGoogle Scholar
  4. Block  C, Peleg  O, Minster  N, Bar-Oz  B, Simhon  A, Arad  I, Cluster of neonatal infections in Jerusalem due to unusual biochemical variant of Enterobacter sakazakii. Eur J Clin Microbiol Infect Dis. 2002;21:613–6. DOIPubMedGoogle Scholar
  5. Joker  RN, Norholm  T, Siboni  KF. A case of neonatal meningitis caused by a yellow Enterobacter. Dan Med Bull. 1965;12:128–30.PubMedGoogle Scholar
  6. Lai  KK. Enterobacter sakazakii infections among neonates, children, and adults. Medicine. 2001;80:113–22. DOIPubMedGoogle Scholar
  7. Monroe  PW, Tift  WL. Bacteremia associated with Enterobacter sakazakii (yellow pigmented Enterobacter cloacae). J Clin Microbiol. 1979;10:850–1.PubMedGoogle Scholar
  8. Muytjens  HL, Zanen  H, Sonderkamp  H, Kollee  L, Wachsmuth  I, Farmer  J. Analysis of eight cases of neonatal meningitis and sepsis due to Enterobacter sakazakii. J Clin Microbiol. 1983;18:115–20.PubMedGoogle Scholar
  9. Van Acker  J, de Smet  F, Muyldermans  G, Bougatef  A, Naessens  A, Lauwers  S. Outbreak of necrotizing enterocolitis associated with Enterobacter sakazakii in powdered milk formula. J Clin Microbiol. 2001;39:293–7. DOIPubMedGoogle Scholar
  10. Simmons  BP, Gelfand  MS, Haas  M, Metts  L, Ferguson  J. Enterobacter sakazakii infections in neonates associated with intrinsic contamination of a powdered milk formula. Infect Control Hosp Epidemiol. 1989;10:398–401. DOIPubMedGoogle Scholar
  11. Nazarowec-White  M, Farber  J. Enterobacter sakazakii: a review. Int J Food Microbiol. 1997;34:103–13. DOIPubMedGoogle Scholar
  12. Arseni  A, Malamou-Ladas  E, Koutsia  C, Xanthou  M, Trikka  E. Outbreak of colonization of neonates with Enterobacter sakazakii. J Hosp Infect. 1987;9:143–50. DOIPubMedGoogle Scholar
  13. Centers for Disease Control and Prevention. Salmonella serotype Tennessee in powdered milk products and infant formula–Canada and United States, 1993. MMWR Morb Mortal Wkly Rep. 1993;42:516–7.PubMedGoogle Scholar
  14. Coignard  B, Vaillant  V, Vincent  JP, Leflèche  A, Mariani-Kurkdjian  P, Bernet  C, Infections sévères à Enterobacter sakazakii chez des nouveau-nés ayant consommé une préparation en poudre pour nourrissons, France, octobre-décembre 2004. Available from: http://www.invs.sante.fr/BEh/2006/02_03/beh_02_03_2006.pdf
  15. Urmenyi  AM, Franklin  AW. Neonatal death from pigmented coliform infection. Lancet. 1961;1:313–5. DOIPubMedGoogle Scholar
  16. Kleiman  MB, Allen  SD, Neal  P, Reynolds  J. Meningoencephalitis and compartmentalization of the cerebral ventricles caused by Enterobacter sakazakii. J Clin Microbiol. 1981;14:352–4.PubMedGoogle Scholar
  17. Naqvi  SH, Maxwell  MA, Dunkle  LM. Cefotaxime therapy of neonatal gram-negative bacillary meningitis. Pediatr Infect Dis. 1985;4:499–502. DOIPubMedGoogle Scholar
  18. Lecour  H, Seara  J, Miranda  M. Treatment of childhood bacterial meningitis. Infection. 1989;17:343–6. DOIPubMedGoogle Scholar
  19. Noriega  FR, Kotloff  KL, Martin  MA, Schwalbe  RS. Nosocomial bacteremia caused by Enterobacter sakazakii and Leuconostoc mesenteroides resulting from extrinsic contamination of infant formula. Pediatr Infect Dis J. 1990;9:447–9. DOIPubMedGoogle Scholar
  20. Gallagher  PG, Ball  WS. Cerebral infarctions due to CNS infection with Enterobacter sakazakii. Pediatr Radiol. 1991;21:135–6. DOIPubMedGoogle Scholar
  21. Stevens  JP, Eames  M, Kent  A, Halket  S, Holt  D, Harvey  D. Long term outcome of neonatal meningitis. Arch Dis Child Fetal Neonatal Ed. 2003;88:F179–84. DOIPubMedGoogle Scholar
  22. Bedford  H, de Louvais  J, Halket  S, Peckham  C, Hurley  R, Harvey  D. Meningitis in infancy in England and Wales: follow up at age 5 years. BMJ. 2001;323:533–6. DOIPubMedGoogle Scholar
  23. Harvey  D, Holt  D, Bedford  H. Bacterial meningitis in the newborn: a prospective study of morbidity and mortality. Semin Perinatol. 1999;23:218–25. DOIPubMedGoogle Scholar
  24. Muytjens  HL, Roelofs-Willemse  H, Jaspar  GH. Quality of powdered substitutes for breast milk with regard to members of the family Enterobacteriaceae. J Clin Microbiol. 1988;26:743–6.PubMedGoogle Scholar
  25. Iversen  C, Forsythe  S. Isolation of Enterobacter sakazakii and other Enterobacteriaceae from powdered infant formula milk and related products. Food Microbiol. 2004;21:771–7. DOIGoogle Scholar
  26. Schuchat  A, Robinson  K, Wenger  J, Harrison  L, Farley  M, Reingold  A, Bacterial meningitis in the United States in 1995. N Engl J Med. 1997;337:970–6. DOIPubMedGoogle Scholar
  27. Wenger  JD, Hightower  AW, Facklam  RR, Gaventa  S, Broome  CV. Bacterial meningitis in the United States, 1986: report of a multistate surveillance study. J Infect Dis. 1990;162:1316–23. DOIPubMedGoogle Scholar
  28. Current marketing and use of powdered infant formula in the United States, 2003, US Food and Drug Administration. Available from http://www.fda.gov/ohrms/dockets/ac/03/briefing/3939b1_tab4c_coversheet.pdf
  29. Kandhai  MC, Reij  MW, Gorris  LG, Guillaume-Gentil  O, van Schothorst  M. Occurrence of Enterobacter sakazakii in food production environments and households. Lancet. 2004;363:39–40. DOIPubMedGoogle Scholar
  30. Hamilton  JV, Lehane  MD, Braig  HR. Isolation of Enterobacter sakazakii from midgut of Stomoxys calcitrans. Emerg Infect Dis. 2003;9:1355–6.PubMedGoogle Scholar
  31. Kuzina  LV, Peloquin  JJ, Vacek  DC, Miller  TA. Isolation and identification of bacteria associated with adult laboratory Mexican fruit flies, Anastrepha ludens. Curr Microbiol. 2001;42:290–4. DOIPubMedGoogle Scholar
  32. Ongradi  J. Medline Vaginal infection by Enterobacter sakazakii. Sex Transm Infect. 2002;78:467–8. DOIPubMedGoogle Scholar
  33. Martin  JA, Hamilton  BE, Sutton  PD, Ventura  SJ, Menacker  F, Munson  ML. Births: final data for 2002. Natl Vital Stat Rep. 2003;52:1–113.PubMedGoogle Scholar
  34. Collins  RN, Treger  MD, Goldsby  JB, Boring  JR, Coohon  DB, Barr  RN. Interstate outbreak of Salmonella newbrunswick infection traced to powdered milk. JAMA. 1968;203:838–44. DOIPubMedGoogle Scholar
  35. Thurm  V, Gericke  B. Identification of infant food as a vehicle in a nosocomial outbreak of Citrobacter freundii: epidemiological subtyping by allozyme, whole-cell protein and antibiotic resistance. J Appl Bacteriol. 1994;76:553–8. DOIPubMedGoogle Scholar
  36. Usera  MA, Echeita  A, Aladuena  A, Blanco  MC, Reymundo  R, Prieto  MI, Interregional foodborne salmonellosis outbreak due to powdered infant formula contaminated with lactose-fermenting Salmonella virchow. Eur J Epidemiol. 1996;12:377–81. DOIPubMedGoogle Scholar
  37. Threlfall  EJ, Ward  LR, Hampton  MD, Ridley  AM, Rowe  B, Roberts  D, Molecular fingerprinting defines a strain of Salmonella enterica serotype anatum responsible for an international outbreak associated with formula-dried milk. Epidemiol Infect. 1998;121:289–93. DOIPubMedGoogle Scholar
  38. Rowe  B, Begg  N, Hutchinson  D, Dawkins  H, Gilbert  R, Jacob  M, Salmonella Ealing infections associated with consumption of infant dried milk. Lancet. 1987;2:900–3. DOIPubMedGoogle Scholar
  39. Enterobacter sakazakii and other microorganisms in powdered infant formula: meeting report. In: Microbiological risk assessment series, no. 6.Geneva: World Health Organization; 2004.
  40. American Dietetic Association. Infant feedings: guidelines for preparation of formula and breast milk in health care facilities, 2003, Washington: American Dietetic Association; 2004.

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Page created: December 09, 2011
Page updated: December 09, 2011
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