TY - JOUR AU - Naas, Thierry AU - Coignard, Bruno AU - Carbonne, Anne AU - Blanckaert, Karine AU - Bajolet, Odile AU - Bernet, Claude AU - Verdeil, Xavier AU - Astagneau, Pascal AU - Desenclos, Jean-Claude AU - Nordmann, Patrice T1 - VEB-1 Extended-Spectrum β-lactamase–producing Acinetobacter baumannii, France T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 8 SP - 1214 SN - 1080-6059 AB - VEB-1 extended-spectrum β-lactamase–producing Acinetobacter baumannii was responsible for an outbreak in hospitals in France. A national alert was triggered in September 2003 when 4 hospitals reported clusters of A. baumannii infection with similar susceptibility profiles. Case definitions and laboratory guidelines were disseminated, and prospective surveillance was implemented; strains were sent to a single laboratory for characterization and typing. From April 2003 through June 2004, 53 hospitals reported 290 cases of A. baumannii infection or colonization; 275 isolates were blaVEB-1-positive and clonally related. Cases were first reported in 5 districts of northern France, then in 10 other districts in 4 regions. Within a region, interhospital spread was associated with patient transfer. In northern France, investigation and control measures led to a reduction of reported cases after January 2004. The national alert enabled early control of new clusters, demonstrating the usefulness of early warning about antimicrobial drug resistance. KW - A. baumannii KW - ESBL KW - VEB-1 KW - outbreak KW - France KW - mandatory notification KW - research DO - 10.3201/eid1208.051547 UR - https://wwwnc.cdc.gov/eid/article/12/8/05-1547_article ER - End of Reference