TY - JOUR AU - Rolain, Jean-Marc AU - Lepidi, Hubert AU - Zanaret, Michel AU - Triglia, Jean-Michel AU - Michel, Gérard AU - Thomas, Pascal-Alexandre AU - Texereau, Michèle AU - Stein, Andreas AU - Romaru, Anette AU - Eb, François AU - Raoult, Didier T1 - Lymph Node Biopsy Specimens and Diagnosis of Cat-scratch Disease T2 - Emerging Infectious Disease journal PY - 2006 VL - 12 IS - 9 SP - 1338 SN - 1080-6059 AB - We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). The specimens were examined by standard, cell culture, and molecular methods. Infectious agents were found in samples from 391 (49.7%) of 786 patients. The most commonly identified infectious agent was Bartonella henselae (245 patients, 31.2%), the agent of CSD. Mycobacteriosis was diagnosed in 54 patients (6.9%) by culture and retrospectively confirmed by using a specific real-time PCR assay. Neoplasm was diagnosed in 181 specimens suitable for histologic analysis (26.0%) from 47 patients. Moreover, 13 patients with confirmed Bartonella infections had concurrent mycobacteriosis (10 cases) or neoplasm (3 cases). A diagnosis of CSD does not eliminate a diagnosis of mycobacteriosis or neoplasm. Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis. KW - Bartonella KW - lymphadenopathy KW - cat-scratch disease KW - 16S rRNA KW - mycobacteria KW - research KW - France DO - 10.3201/eid1209.060122 UR - https://wwwnc.cdc.gov/eid/article/12/9/06-0122_article ER - End of Reference