Volume 13, Number 1—January 2007
Research
Similar Biochemical Signatures and Prion Protein Genotypes in Atypical Scrapie and Nor98 Cases, France and Norway
Jean-Noël Arsac*, Olivier Andreoletti†, Jean-Marc Bilheude‡, Caroline Lacroux†, Sylvie L. Benestad§, and Thierry G.M. Baron*
Table
Atypical, Nor98, and classic scrapie isolates from sheep and goats and distribution of genotypes*
| Sheep isolates | Goat isolates | |||||
|---|---|---|---|---|---|---|
| Genotype | Atypical, n = 51 (no. of fully characterized isolates) | Nor98, n = 4 | Classic, n = 74 | Atypical, n = 3 | Classic, n = 60 | |
| AF141RQ/ | ARR | 16 (3) | 1 (0) | – | – | – |
| ARQ | 9 (3) | – | 5 | – | – | |
| AF141RQ | 7 (3) | 1 (0) | – | – | – | |
| VRQ | 3 (0) | – | 4 | – | – | |
| AHQ/ | ARR | 2 (1) | – | – | – | – |
| AHQ | 2 (0) | 2 (1) | – | 1 (1) | – | |
| ARQ | 1 (0) | – | – | 1 (1) | – | |
| ARH | 1 (1) | – | – | – | – | |
| VRQ | 1 (0) | – | – | – | – | |
| ARR/ | ARR | 6 (3) | – | – | – | – |
| ARQ/ | ARR | 2 (2) | – | – | – | – |
| ARQ | – | – | 29 | 1 (0) | 60 | |
| ARH | – | – | 13 | – | – | |
| ARH/ | ARH | 1 (1) | – | 3 | – | – |
| VRQ/ | ARQ | – | – | 10 | – | – |
| VRQ | – | – | 9 | – | – | |
| ARH | – | – | 1 | – | – | |
*Amino acids encoded at positions 136, 141, 154, and 171 are indicated.
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