TY - JOUR AU - Hunter, Paul R. AU - Hadfield, Stephen J. AU - Wilkinson, Dawn AU - Lake, Iain R. AU - Harrison, Florence C.D. AU - Chalmers, Rachel M. T1 - Correlation between Subtypes of Cryptosporidium parvum in Humans and Risk T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 1 SP - 82 SN - 1080-6059 AB - The 2 main species of Cryptosporidium that infect humans are Cryptosporidium hominis and C. parvum. Here, multilocus fragment analysis of 3 microsatellite loci (ML1, ML2, and gp60) was used to subtype strains from sporadic cases of cryptosporidiosis in Wales and northwest England. Of 72 strains of C. parvum, 63 were typeable at all 3 loci, forming 31 subtypes. These strains formed 3 broad clusters, representing 74.6%, 20.6%, and 4.8% of typeable strains. Of 118 C. hominis strains, 106 were typeable at all 3 loci, forming 9 subtypes; however, 90% belonged to the same subtype. Analysis with epidemiologic data found an association between strains from case-patients who reported contact with farm animals and individual C. parvum microsatellite alleles. The strongest association was with ML1; all strains from case-patients that reported farm animal contact had the same allele (ML1–242). Microsatellite typing of C. parvum provides valuable additional information on the epidemiology of this pathogen. KW - Cryptosporidium KW - microsatellite typing KW - discriminatory power KW - zoonoses KW - research KW - United Kingdom DO - 10.3201/eid1301.060481 UR - https://wwwnc.cdc.gov/eid/article/13/1/06-0481_article ER - End of Reference