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Volume 13, Number 8—August 2007

Infection with Scedosporium apiospermum and S. prolificans, Australia

Louise Cooley*†, Denis Spelman*, Karin Thursky‡, and Monica Slavin*‡Comments to Author 
Author affiliations: *Alfred Hospital, Prahran, Victoria, Australia; †Royal Hobart Hospital, Hobart, Tasmania, Australia; ‡Royal Melbourne Hospital, Parkville, Victoria, Australia;

Main Article

Table 1

Characteristics and outcomes of patients infected with Scedosporium spp., Australia, 1997–2003

CharacteristicS. apiospermumS. prolificans
No. patients3128
Patient demographics
  Mean age (range), y4042
  Sex (M:F)
Immunocompromised (%)21 (68)14 (50)
  Stem cell transplant06
  Hematologic malignancy02
  Lung and/or heart transplant136
  HIV infection, cancer, immunosuppression80
Immunocompetent (%)10 (32)14 (50)
  Cystic fibrosis56
  Airways disease*43
  Other condition†
Specimen type
  Respiratory tract (%)27 (68)20 (71)
Additional microorganisms identified (%)16 (42)14 (50)
Outcome at 1 mo
  Invasive infection (%)#2 (6)10 (36)
  Died at 1 mo (%)**6 (19)5 (18)
  Died of scedosporiosis (%)††1 (3)5 (18)
  Attributable mortality rate of invasive disease (%)‡‡1/2 (50)5/10 (50)

*Bronchiectasis, asthma, and chronic obstructive pulmonary disease.
†Osteoarthritis and trauma.
‡Ear swab, central catheter tip, and synovial fluid.
§Aspergillus spp, Rhizopus orrhyzae, and Paecilomyces sp.
¶Bacteria not found in normal flora included Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Staphylococcus aureus, Nocardia sp., and Mycobacterium avium complex.
#Odds ratio (OR) 6.64, 95% confidence interval (CI) 1.62–27.12, p = 0.001.
**OR 1.11, 95% CI 0.40–3.04, p = 0.84.
††OR 5.53, 95% CI 0.68–44.54, p = 0.06.
‡‡OR 1.0, 95% CI 0.21–4.56, p = 1.0.

Main Article

Page created: June 30, 2010
Page updated: June 30, 2010
Page reviewed: June 30, 2010
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