TY - JOUR AU - Harris, Anthony D. AU - McGregor, Jessina C. AU - Johnson, Judith A. AU - Strauss, Sandra M. AU - Moore, Anita C. AU - Standiford, Harold C. AU - Hebden, Joan N. AU - Morris, J. Glenn T1 - Risk Factors for Colonization with Extended-Spectrum β-Lactamase–producing Bacteria and Intensive Care Unit Admission T2 - Emerging Infectious Disease journal PY - 2007 VL - 13 IS - 8 SP - 1144 SN - 1080-6059 AB - Extended-spectrum β-lactamase (ESBL)–producing bacteria are emerging pathogens. To analyze risk factors for colonization with ESBL-producing bacteria at intensive care unit (ICU) admission, we conducted a prospective study of a 3.5-year cohort of patients admitted to medical and surgical ICUs at the University of Maryland Medical Center. Over the study period, admission cultures were obtained from 5,209 patients. Of these, 117 were colonized with ESBL-producing Escherichia coli and Klebsiella spp., and 29 (25%) had a subsequent ESBL-positive clinical culture. Multivariable analysis showed the following to be statistically associated with ESBL colonization at admission: piperacillin-tazobactam (odds ratio [OR] 2.05, 95% confidence interval [CI] 1.36–3.10), vancomycin (OR 2.11, 95% CI 1.34–3.31), age >60 years (OR 1.79, 95% CI 1.24–2.60), and chronic disease score (OR 1.15; 95% CI 1.04–1.27). Coexisting conditions and previous antimicrobial drug exposure are thus predictive of colonization, and a large percentage of these patients have subsequent positive clinical cultures for ESBL-producing bacteria. KW - Drug-resistance microbial KW - risk factors KW - intensive care units KW - beta lactamases KW - Escherichia coli KW - Klebsiella KW - research KW - United States DO - 10.3201/eid1308.070071 UR - https://wwwnc.cdc.gov/eid/article/13/8/07-0071_article ER - End of Reference