Volume 13, Number 9—September 2007
Research
Family Clustering of Viliuisk Encephalomyelitis in Traditional and New Geographic Regions
Vsevolod A. Vladimirtsev*, Raisa S. Nikitina*, Neil Renwick†, Anastasia A. Ivanova*, Al’bina P. Danilova*, Fyodor A. Platonov*, Vadim G. Krivoshapkin*, Catriona A. McLean‡, Colin L. Masters‡, D. Carleton Gajdusek§, and Lev G. Goldfarb¶
Table 2
Laboratory investigations and postmortem findings in Viliuisk encephalomyelitis patients from 6 families*
| Laboratory and postmortem findings | Family 1 |
Family 2 |
Family 3 |
Family 4 |
Family 5 |
Family 6 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-1 | 1-2 | 1-3 | 2-1 | 2-2 | 3-1 | 3-2 | 4-1 | 4-2 | 4-3 | 5-1 | 5-2 | 6-1 | 6-2 | 6-3 | |
| Cerebrospinal fluid | |||||||||||||||
| Cell count (cells/μL) | 20–102 | 8 | 3 | 45–62 | 15–44 | 2 | 11–58 | 25 | 17 | 4– 18 | NA | 12 | NA | 17–65 | 11–27 |
| Predominant cell type | Lym | Lym | Lym | Lym | Lym | Lym | |||||||||
| Protein (mg/dL) | 150 | 166 | 23 | 480 | 99 | 16 | 99 | 33 | 66 | 132 | 66 | 66 | 99 | ||
| Bacterial culture | Neg | Neg | NA | Neg | Neg | NA | Neg | NA | NA | NA | NA | Neg | Neg | ||
| Postmortem | |||||||||||||||
| Inflamed meninges | + | + | + | + | + | + | |||||||||
| Micronecrotic lesions in the brain parenchyma | + | + | + | + | + | + | |||||||||
*NA, data not available; Lym, lymphocytes; Neg, negative; +, observed.
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