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Volume 13, Number 9—September 2007

TaqMan Assay for Swedish Chlamydia trachomatis Variant

Arnold Catsburg*1, Laura van Dommelen†1, Vitaly Smelov‡§, Henry J.C. de Vries¶#, Alevtina Savitcheva‡, Marius Domeika**, Björn Herrmann††, Sander Ouburg*, Christian J.P.A. Hoebe‡‡, Anders Nilsson††, Paul H.M. Savelkoul*, and Servaas A. Morré*†§§Comments to Author 
Author affiliations: *VU University Medical Center, Amsterdam, the Netherlands; †Academic Hospital Maastricht, Maastricht, the Netherlands; ‡D.O. Ott Research Institute of Obstetrics and Gynaecology, St. Petersburg, Russia; §St. Petersburg State University, St. Petersburg, Russia; ¶Health Service Amsterdam, Amsterdam, the Netherlands; #University of Amsterdam, Amsterdam, the Netherlands; **Uppsala University, Uppsala, Sweden; ††Uppsala University Hospital, Uppsala, Sweden; ‡‡South Limburg Public Health Service, Heerlen, the Netherlands; §§City of Hope and Beckman Research Institute, Duarte, California, USA;

Main Article


Published studies and the current study on screening for the swCT variant*

Location Ct+, 
no. detected swCT variant, 
no. detected Reference
Amsterdam, the Netherlands 75 ND (3)
Dublin, Ireland 750 ND (4)
Oslo, Norway† 47 2 (5)
St. Petersburg, Russia 152 ND This study
Heerlen, the Netherlands 57 ND This study
Amsterdam, the Netherlands 30 ND This study

*swCT, Swedish Chlamydia trachomatis variant identified in Halland County, Sweden; Ct+, C. trachomatis DNA; ND, not detected.
†2 female patients: 1 originally from Sweden, 1 from Norway.

Main Article

  1. Soderblom  T, Blaxhult  A, Fredlund  H, Herrmann  B. Impact of a genetic variant of Chlamydia trachomatis on national detection rates in Sweden. Euro Surveill. 2006;11:E061207.1.
  2. de Vries  HJC, Catsburg  A, van der Helm  JJ, Beukelaar  EC, Morré  SA, Fennema  JSA, No indication of Swedish Chlamydia trachomatis variant among STI clinic visitors in Amsterdam. Euro Surveill. 2007;12:E070208.3.
  3. Lynagh  Y, Crowley  B, Walsh  A. Investigation to determine if newly-discovered variant of Chlamydia trachomatis is present in Ireland. Euro Surveill. 2007;12:E070201.2.
  4. Moghaddam  A, Reinton  N. Identification of the Swedish Chlamydia trachomatis variant among patients attending a STI clinic in Oslo, Norway. Euro Surveill. 2007;12:E070301.3.
  5. de Laar  V, Ison  C. Europe-wide investigation to assess the presence of new variant of Chlamydia trachomatis in Europe. Euro Surveill. 2007;12:E070208.4.
  6. Ripa  T, Nilsson  PA. A Chlamydia trachomatis strain with a 377-bp deletion in the cryptic plasmid causing false-negative nucleic acid amplification tests. Sex Transm Dis. 2007;34:2556.PubMedGoogle Scholar
  7. Catsburg  A, van der Zwet  WC, Morré  SA, Ouburg  S, Vandenbroucke-Grauls  CM, Savelkoul  PH. Analysis of multiple single nucleotide polymorphisms (SNP) on DNA traces from plasma and dried blood samples. J Immunol Methods. 2007;321:13541. DOIPubMedGoogle Scholar
  8. Savitcheva  A, Smirnova  T, Pavlova  N, Bashmakova  M, Shishkina  O, Novikov  B, Diagnosis and treatment of genital Chlamydia trachomatis infection in St. Petersburg and Leningradskaya Oblastj. In: Domeika M., Hallen A., editors. Chlamydia trachomatis infection in Eastern Europe. Uppsala (Sweden): Uppsala University; 2000.
  9. Morré  SA, Sillekens  P, Jacobs  MV, van Aarle  P, de Blok  S, van Gemen  B, RNA amplification by nucleic acid sequence-based amplification with an internal standard enables reliable detection of Chlamydia trachomatis in cervical scrapings and urine samples. J Clin Microbiol. 1996;34:310814.PubMedGoogle Scholar
  10. Morré  SA, Spaargaren  J, Fennema  JSA, de Vries  HJC, Peña  AS. Real-time PCR for the rapid one-step diagnosis of Chlamydia trachomatis LGV infection to help manage and contain the current outbreak in Europe and the USA. Emerg Infect Dis. 2005;11:13112.PubMedGoogle Scholar

Main Article

1These authors contributed equally to the study.

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