TY - JOUR AU - Manges, Amee R. AU - Tabor, Helen AU - Tellis, Patricia AU - Vincent, Caroline AU - Tellier, Pierre-Paul T1 - Endemic and Epidemic Lineages of Escherichia coli that Cause Urinary Tract Infections T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 10 SP - 1575 SN - 1080-6059 AB - Women with urinary tract infections (UTIs) in California, USA (1999–2001), were infected with closely related or indistinguishable strains of Escherichia coli (clonal groups), which suggests point source dissemination. We compared strains of UTI-causing E. coli in California with strains causing such infections in Montréal, Québec, Canada. Urine specimens from women with community-acquired UTIs in Montréal (2006) were cultured for E. coli. Isolates that caused 256 consecutive episodes of UTI were characterized by antimicrobial drug susceptibility profile, enterobacterial repetitive intergenic consensus 2 PCR, serotyping, XbaI and NotI pulsed-field gel electrophoresis, multilocus sequence typing, and phylogenetic typing. We confirmed the presence of drug-resistant, genetically related, and temporally clustered E. coli clonal groups that caused community-acquired UTIs in unrelated women in 2 locations and 2 different times. Two clonal groups were identified in both locations. Epidemic transmission followed by endemic transmission of UTI-causing clonal groups may explain these clusters of UTI cases. KW - Escherichia coli KW - molecular epidemiology KW - urinary tract infections KW - extraintestinal infections KW - antimicrobial drug resistance KW - research KW - United States KW - Canada DO - 10.3201/eid1410.080102 UR - https://wwwnc.cdc.gov/eid/article/14/10/08-0102_article ER - End of Reference