TY - JOUR AU - Gavidia, Cesar M. AU - Gonzalez, Armando E. AU - Zhang, Wenbao AU - McManus, Donald P. AU - Lopera, Luis AU - Ninaquispe, Berenice AU - Garcia, Hector H. AU - Rodríguez, Silvia AU - Verastegui, Manuela AU - Calderon, Carmen AU - Pan, William K.Y. AU - Gilman, Robert H. T1 - Diagnosis of Cystic Echinococcosis, Central Peruvian Highlands T2 - Emerging Infectious Disease journal PY - 2008 VL - 14 IS - 2 SP - 260 SN - 1080-6059 AB - We evaluated prevalence of cystic echinococcosis (CE) in a central Peruvian Highland district by using 4 diagnostic methods: ultrasonography for 949 persons, radiography for 829, and 2 serologic tests for 929 (2 immunoblot formats using bovine hydatid cyst fluid [IBCF] and recombinant EpC1 glutathione S-transferase [rEpC1-GST] antigens). For the IBCF and rEpC1-GST testing, prevalence of liver and pulmonary CE was 4.7% and 1.1% and seropositivity was 8.9% and 19.7%, respectively. Frequency of seropositive results for IBCF and rEpC1-GST testing was 35.7% and 16.7% (all hepatic cysts), 47.1% and 29.4% (hepatic calcifications excluded), and 22.2% and 33.3% (lung cysts), respectively. Weak immune response against lung cysts, calcified cysts, small cysts, and cysts in sites other than lung and liver might explain the poor performance of the serodiagnostic tests. We confirm that CE is highly endemic to Peru and emphasize the limited performance of available serologic assays in the field. KW - Cystic echinococcosis KW - diagnostic-test prevalence KW - IBCF KW - rEpC1-GST KW - ultrasound KW - X-ray KW - Peru KW - research DO - 10.3201/eid1402.061101 UR - https://wwwnc.cdc.gov/eid/article/14/2/06-1101_article ER - End of Reference