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Volume 14, Number 8—August 2008

Systematic Literature Review of Role of Noroviruses in Sporadic Gastroenteritis

Manish M. Patel*Comments to Author , Marc-Alain Widdowson*, Roger I. Glass*†, Kenichiro Akazawa‡, Jan Vinjé*, and Umesh D. Parashar*
Author affiliations: *Centers for Disease Control and Prevention, Atlanta, Georgia, USA; †National Institutes of Health, Bethesda, Maryland, USA; ‡Chigasaki Tokushukai Medical Center, Kanagawa, Japan;

Main Article

Table 2

Summary of studies that examined prevalence of NoV in persons with severe sporadic AGE, emergency department visits and hospitalizations, by using RT-PCR for >12 months*

RefCountryStudy duration, moAge group, yNo. AGE casesNo. NoV positive (single and mixed)% NoV positiveNo. NoV positive (mixed)% MixedNo. control patients% Controls positive for NoV
Emergency department
25 and 17§

(13)‡Hong Kong12All73512316.7
(37)South Korea24<596213213.7181.9
(18)‡Chile25 and 17§<516284.9500.0
(31)South Africa48All1,296322.5
(41)South Korea12<576211415.0

*NoV, norovirus; AGE, acute gastroenteritis; RT-PCR, reverse transcription–PCR; Ref, reference; –, not assessed in the study.
†NoV prevalence (total and mixed alone) in these studies was estimated by multiplying the calicivirus prevalence by average proportion fo caliciviruses determined to be NoV (88.5%) among hospital-based studies reporting NoV and sapovirus results separately.
‡O’Ryan et al. (18) included clinic-, emergency department–, and hospital-based patients; Lau et al. (13), Monica et al. (33), and Sdiri-Loulizi et al. (34) included community/clinic- and hospital-based patients. Only emergency department and hospitalization data are presented here.
§Included 2 hospitals with 25- and 17-month enrollment periods.
¶98% (213 of 217) of the case-patients were <5 y of age.
#Age- and setting-specific data were obtained through personal communication with the author.

Main Article

  1. Bryce J, Boschi-Pinto C, Shibuya K, Black RE; WHO Child Health Epidemiology Reference Group.WHO estimates of the causes of death in children.Lancet. 2005;365:114752. DOIPubMedGoogle Scholar
  2. Green KY. Caliciviridae: the noroviruses. In: Knipe DM, Howley PM, editors. Fields virology, 5th ed., vol. 1. Philadelphia: Lippincott Williams & Wilkins; 2007. p. 949–78.
  3. Lopman B. Noroviruses: simple detection for complex epidemiology.Clin Infect Dis. 2006;42:9701. DOIPubMedGoogle Scholar
  4. Glass RI, Noel J, Ando T, Fankhauser R, Belliot G, Mounts A, The epidemiology of enteric caliciviruses from humans: a reassessment using new diagnostics.J Infect Dis. 2000;181(Suppl 2):S25461. DOIPubMedGoogle Scholar
  5. Widdowson MA, Monroe SS, Glass RI. Are noroviruses emerging?Emerg Infect Dis. 2005;11:7357.PubMedGoogle Scholar
  6. Amar CF, East CL, Gray J, Iturriza-Gomara M, Maclure EA, McLauchlin J. Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: re-examination of the English case-control Infectious Intestinal Disease Study (1993–1996).Eur J Clin Microbiol Infect Dis. 2007;26:31123. DOIPubMedGoogle Scholar
  7. Lopman BA, Reacher MH, Vipond IB, Hill D, Perry C, Halladay T, Epidemiology and cost of nosocomial gastroenteritis, Avon, England, 2002–2003.Emerg Infect Dis. 2004;10:182734.PubMedGoogle Scholar
  8. Lopman BA, Reacher MH, Vipond IB, Sarangi J, Brown DW. Clinical manifestation of norovirus gastroenteritis in health care settings.Clin Infect Dis. 2004;39:31824. DOIPubMedGoogle Scholar
  9. Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI. Global illness and deaths caused by rotavirus disease in children.Emerg Infect Dis. 2003;9:56572.PubMedGoogle Scholar
  10. Widdowson MA, Meltzer MI, Zhang X, Bresee JS, Parashar UD, Glass RI. Cost-effectiveness and potential impact of rotavirus vaccination in the United States.Pediatrics. 2007;119:68497. DOIPubMedGoogle Scholar
  11. Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der Wielen M, Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004-2005: the REVEAL study.J Infect Dis. 2007;195(Suppl 1):S416. DOIPubMedGoogle Scholar
  12. Bon F, Fascia P, Dauvergne M, Tenenbaum D, Planson H, Petion AM, Prevalence of group A rotavirus, human calicivirus, astrovirus, and adenovirus type 40 and 41 infections among children with acute gastroenteritis in Dijon, France.J Clin Microbiol. 1999;37:30558.PubMedGoogle Scholar
  13. Lau CS, Wong DA, Tong LK, Lo JY, Ma AM, Cheng PK, High rate and changing molecular epidemiology pattern of norovirus infections in sporadic cases and outbreaks of gastroenteritis in Hong Kong.J Med Virol. 2004;73:1137. DOIPubMedGoogle Scholar
  14. Marshall JA, Hellard ME, Sinclair MI, Fairley CK, Cox BJ, Catton MG, Incidence and characteristics of endemic Norwalk-like virus-associated gastroenteritis.J Med Virol. 2003;69:56878. DOIPubMedGoogle Scholar
  15. de Wit MA, Koopmans MP, Kortbeek LM, Wannet WJ, Vinjé J, van Leusden F, Sensor, a population-based cohort study on gastroenteritis in the Netherlands: incidence and etiology.Am J Epidemiol. 2001;154:66674. DOIPubMedGoogle Scholar
  16. de Wit MA, Koopmans MP, Kortbeek LM, van Leeuwen NJ, Bartelds AI, van Duynhoven YT. Gastroenteritis in sentinel general practices, the Netherlands.Emerg Infect Dis. 2001;7:8291.PubMedGoogle Scholar
  17. Pang XL, Joensuu J, Vesikari T. Human calicivirus-associated sporadic gastroenteritis in Finnish children less than two years of age followed prospectively during a rotavirus vaccine trial.Pediatr Infect Dis J. 1999;18:4206. DOIPubMedGoogle Scholar
  18. O’Ryan ML, Mamani N, Gaggero A, Avendaño LF, Prieto S, Peña A, Human caliciviruses are a significant pathogen of acute sporadic diarrhea in children of Santiago, Chile.J Infect Dis. 2000;182:151922. DOIPubMedGoogle Scholar
  19. Phan TG, Takanashi S, Kaneshi K, Ueda Y, Nakaya S, Nishimura S, Detection and genetic characterization of norovirus strains circulating among infants and children with acute gastroenteritis in Japan during 2004–2005.Clin Lab (Zaragoza). 2006;52:51925.
  20. Phan TG, Nguyen TA, Kuroiwa T, Kaneshi K, Ueda Y, Nakaya S, Viral diarrhea in Japanese children: results from a one-year epidemiologic study.Clin Lab (Zaragoza). 2005;51:18391.
  21. Phan TG, Kuroiwa T, Kaneshi K, Ueda Y, Nakaya S, Nishimura S, Changing distribution of norovirus genotypes and genetic analysis of recombinant GIIb among infants and children with diarrhea in Japan.J Med Virol. 2006;78:9718. DOIPubMedGoogle Scholar
  22. Boga JA, Melon S, Nicieza I, De Diego I, Villar M, Parra F, Etiology of sporadic cases of pediatric acute gastroenteritis in asturias, Spain, and genotyping and characterization of norovirus strains involved.J Clin Microbiol. 2004;42:266874. DOIPubMedGoogle Scholar
  23. Dove W, Cunliffe NA, Gondwe JS, Broadhead RL, Molyneux ME, Nakagomi O, Detection and characterization of human caliciviruses in hospitalized children with acute gastroenteritis in Blantyre, Malawi.J Med Virol. 2005;77:5227. DOIPubMedGoogle Scholar
  24. Hansman GS, Doan LT, Kguyen TA, Okitsu S, Katayama K, Ogawa S, Detection of norovirus and sapovirus infection among children with gastroenteritis in Ho Chi Minh City, Vietnam.Arch Virol. 2004;149:167388. DOIPubMedGoogle Scholar
  25. Hansman GS, Katayama K, Maneekarn N, Peerakome S, Khamrin P, Tonusin S, Genetic diversity of norovirus and sapovirus in hospitalized infants with sporadic cases of acute gastroenteritis in Chiang Mai, Thailand.J Clin Microbiol. 2004;42:13057. DOIPubMedGoogle Scholar
  26. Kirkwood CD, Clark R, Bogdanovic-Sakran N, Bishop RF. A 5-year study of the prevalence and genetic diversity of human caliciviruses associated with sporadic cases of acute gastroenteritis in young children admitted to hospital in Melbourne, Australia (1998-2002).J Med Virol. 2005;77:96101. DOIPubMedGoogle Scholar
  27. Oh DY, Gaedicke G, Schreier E. Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity.J Med Virol. 2003;71:8293. DOIPubMedGoogle Scholar
  28. Parashar UD, Li JF, Cama R, DeZalia M, Monroe SS, Taylor DN, Human caliciviruses as a cause of severe gastroenteritis in Peruvian children.J Infect Dis. 2004;190:108892. DOIPubMedGoogle Scholar
  29. Sanchez-Fauquier A, Montero V, Moreno S, Solé M, Colomina J, Iturriza-Gomara M, Human rotavirus G9 and G3 as major cause of diarrhea in hospitalized children, Spain.Emerg Infect Dis. 2006;12:153641.PubMedGoogle Scholar
  30. Schnagl RD, Barton N, Patrikis M, Tizzard J, Erlich J, Morey F. Prevalence and genomic variation of Norwalk-like viruses in central Australia in 1995-1997.Acta Virol. 2000;44:26571.PubMedGoogle Scholar
  31. Wolfaardt M, Taylor MB, Booysen HF, Engelbrecht L, Grabow WO, Jiang X. Incidence of human calicivirus and rotavirus infection in patients with gastroenteritis in South Africa.J Med Virol. 1997;51:2906. DOIPubMedGoogle Scholar
  32. Zintz C, Bok K, Parada E, Barnes-Eley M, Berke T, Staat MA, Prevalence and genetic characterization of caliciviruses among children hospitalized for acute gastroenteritis in the United States.Infect Genet Evol. 2005;5:28190. DOIPubMedGoogle Scholar
  33. Monica B, Ramani S, Banerjee I, Primrose B, Iturriza-Gomara M, Gallimore CI, Human caliciviruses in symptomatic and asymptomatic infections in children in Vellore, South India.J Med Virol. 2007;79:54451. DOIPubMedGoogle Scholar
  34. Sdiri-Loulizi K, Gharbi-Khelifi H, de Rougemont A, Chouchane S, Sakly N, Ambert-Balay K, Acute infantile gastroenteritis associated with human enteric viruses in Tunisia.J Clin Microbiol. 2008;46:134955. Epub 2008 Feb 20. DOIPubMedGoogle Scholar
  35. Colomba C, Saporito L, Giammanco GM, De Grazia S, Ramirez S, Arista S, Norovirus and gastroenteritis in hospitalized children, Italy.Emerg Infect Dis. 2007;13:138991.PubMedGoogle Scholar
  36. Khamrin P, Maneekarn N, Peerakome S, Tonusin S, Malasao R, Mizuguchi M, Genetic diversity of noroviruses and sapoviruses in children hospitalized with acute gastroenteritis in Chiang Mai, Thailand.J Med Virol. 2007;79:19216. DOIPubMedGoogle Scholar
  37. Lee JI, Chung JY, Han TH, Song MO, Hwang ES. Detection of human bocavirus in children hospitalized because of acute gastroenteritis.J Infect Dis. 2007;196:9947. DOIPubMedGoogle Scholar
  38. Onishi N, Hosoya M, Matsumoto A, Imamura T, Katayose M, Kawasaki Y, Molecular epidemiology of norovirus gastroenteritis in Soma, Japan, 2001-2003.Pediatr Int. 2008;50:659. DOIPubMedGoogle Scholar
  39. Papaventsis DC, Dove W, Cunliffe NA, Nakagomi O, Combe P, Grosjean P, Norovirus infection in children with acute gastroenteritis, Madagascar, 2004–2005.Emerg Infect Dis. 2007;13:90811.PubMedGoogle Scholar
  40. Victoria M, Carvalho-Costa FA, Heinemann MB, Leite JP, Miagostovich M. Prevalence and molecular epidemiology of noroviruses in hospitalized children with acute gastroenteritis in Rio de Janeiro, Brazil, 2004.Pediatr Infect Dis J. 2007;26:6026. DOIPubMedGoogle Scholar
  41. Yoon JS, Lee SG, Hong SK, Lee SA, Jheong WH, Oh SS, Molecular epidemiology of norovirus infections in children with acute gastroenteritis in South Korea, November 2005 through November 2006.J Clin Microbiol. 2008;46:14747. Epub 2008 Feb 13. DOIPubMedGoogle Scholar

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