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Volume 15, Number 1—January 2009

Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004–2005

Nguyen Duc Hien, Nguyen Hong Ha, Nguyen Tuong Van, Nguyen Thi Minh Ha, Trinh Thi Minh Lien, Nguyen Quoc Thai, Van Dinh Trang, Takuro ShimboComments to Author , Yoshimitsu Takahashi, Yasuyuki Kato, Akihiko Kawana, Samu Akita, and Koichiro Kudo
Author affiliations: National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam (N.D. Hien, N.H. Ha, N.T. Van, N.T.M. Ha, T.T.M. Lien, N.Q. Thai, V.D. Trang); International Medical Center of Japan, Tokyo, Japan (T. Shimbo, Y. Takahashi, Y. Kato, A. Kawana, S. Akita, K. Kudo)

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Table 2

Initial laboratory and chest radiographic results for 29 patients infected with highly pathogenic avian influenza virus (H5N1), northern Vietnam, 2004–2005*

Characteristic Survived, median (interquartile range), 
n = 22 Died, median (interquartile range), 
n = 7 p value
Leukocytes, × 103/μL 7.8 (7.1–12.0) 3.4 (1.7–5.6)† 0.0093
Neutrophils, ×103/μL 6.8 (4.8–9.9) 2.3 (1.1–3.8)† 0.0101
Hemoglobin, g/L 130 (107–137) 121 (103–138) 0.6102
Platelets, × 103/μL 214 (181–284) 86 (38–139)† 0.0101
Albumin, g/L 34.5 (31.2–35.1) 21.7 (10.4–29.4)† 0.0265
AST, U/L 45 (28–69) 327 (77–352)† 0.0077
Total bilirubin, μmol/L 10.3 (7.6–16.8) 11.4 (7.0–27.1) 0.7921
Urea nitrogen, mmol/L
4.5 (3.4–5.5)
9 (3.4–14.3)†
Initial chest radiographic findings‡
No or slight lesion 7 1 0.6510
Moderate lesion 10 3
Severe lesion 5 3

*Not all laboratory findings and chest radiographic results were available. Results were derived from the following numbers of patients: complete blood count, 29; albumin 12; AST, 25; total bilirubin, 17; urea nitrogen, 27. AST, aspartate aminotransferase.
†p<0.05, by Wilcoxon test or Fisher exact test.
‡No or slight lesion, no lesion or localized (occupying less than one third of unilateral lung fields) in 1 lung; moderate, diffuse in 1 lung or localized but evident in both lungs; severe, diffuse in both lungs.

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Page created: November 19, 2010
Page updated: November 19, 2010
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