TY - JOUR AU - Hien, Nguyen Duc AU - Ha, Nguyen Hong AU - Van, Nguyen Tuong AU - Ha, Nguyen Thi Minh AU - Lien, Trinh Thi Minh AU - Thai, Nguyen Quoc AU - Trang, Van Dinh AU - Shimbo, Takuro AU - Takahashi, Yoshimitsu AU - Kato, Yasuyuki AU - Kawana, Akihiko AU - Akita, Samu AU - Kudo, Koichiro T1 - Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004–2005 T2 - Emerging Infectious Disease journal PY - 2009 VL - 15 IS - 1 SP - 19 SN - 1080-6059 AB - We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection, a history of high-risk exposure or chest radiographic findings such as pneumonia, and positive findings for A/H5 viral RNA by reverse transcription–PCR. We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died. Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively. After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone. KW - Influenza A virus KW - H5N1 subtype KW - respiratory tract infection KW - antiviral drugs KW - neuraminidase inhibitors KW - mortality KW - research KW - Vietnam DO - 10.3201/eid1501.080073 UR - https://wwwnc.cdc.gov/eid/article/15/1/08-0073_article ER - End of Reference