TY - JOUR AU - John, Chandy C. AU - Riedesel, Melissa A. AU - Magak, Ng’wena G. AU - Lindblade, Kim A. AU - Menge, David M. AU - Hodges, James S. AU - Vulule, John M. AU - Akhwale, Willis T1 - Possible Interruption of Malaria Transmission, Highland Kenya, 2007–2008 T2 - Emerging Infectious Disease journal PY - 2009 VL - 15 IS - 12 SP - 1917 SN - 1080-6059 AB - Highland areas where malaria transmission is unstable are targets for malaria elimination because transmission decreases to low levels during the dry season. In highland areas of Kipsamoite and Kapsisiywa, Kenya (population ≈7,400 persons), annual household indoor residual spraying with a synthetic pyrethroid was performed starting in 2005, and artemether/lumefantrine was implemented as first-line malaria treatment in October 2006. During April 2007–March 2008, no microscopy-confirmed cases of malaria occurred at the sites. In 4 assessments of asymptomatic persons during May 2007–April 2008, a total of <0.3% of persons were positive for asexual Plasmodium falciparum by microscopy or PCR at any time, and none were positive by PCR at the last 2 sample collections. Our findings show that in such areas, interruption and eventual elimination of malaria transmission may be achievable with widespread annual indoor residual spraying of households and artemisinin combination therapy. KW - Malaria KW - transmission KW - Plasmodium falciparum KW - epidemiology KW - Kenya KW - parasites KW - research DO - 10.3201/eid1512.090627 UR - https://wwwnc.cdc.gov/eid/article/15/12/09-0627_article ER - End of Reference