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Volume 15, Number 3—March 2009

Sudden Increases in Listeriosis Rates in England and Wales, 2001 and 2003

Benjamin J. CairnsComments to Author  and Robert J.H. Payne
Author affiliations: University of Bristol, Bristol, UK

Main Article

Table 2

Estimated coefficients for terms in the best fit model for the monthly incidence of listeriosis*†

Variable Coefficient 95% Confidence interval Unadjusted p value Adjusted p value
(Intercept) 1.5430 1.3961–1.6879 <0.001 <0.001
GEAPR01 0.3424 0.1594–0.5243 <0.001 0.001
GEMAR03 0.3904 0.2462– 0.5373 <0.001 <0.001
MEANTEMP 0.0239 0.0055–0.0424 0.011 0.044
MEANTEMP1 0.0401 0.0217–0.0586 <0.001 <0.001
MONTHNUM –0.0013 –0.0027–0.0001 0.063 0.188
ANOMALY1 0.0246 –0.0246–0.0739 0.327 0.327
ANOMALY1×GEAPR01 0.0556 –0.0212–0.1323 0.156 0.312
θ (theta) 600.41 NA NA NA

*NA, not applicable.
†p values are for 2-sided tests of significance of the difference of each coefficient from zero; adjusted p values are according to Holm’s method (10). Percentage changes in the main text can be derived from these coefficients by taking exponentials, subtracting 1, and multiplying by 100.

Main Article

  1. de Valk  H, Jacquet  C, Goulet  V, Vaillant  V, Perra  A, Desenclos  J-C, ; Listeria Working Group. Feasibility study for a collaborative surveillance of Listeria infections in Europe; report to the European Commission. Paris: DGSANCO; Mar 2003 [cited 2008 Jul 8]. Available from
  2. Koch  J, Stark  K. Significant increase of listeriosis in Germany–—epidemiological patterns 2001–2005. Euro Surveill. 2006;11:858.PubMedGoogle Scholar
  3. Gillespie  IA, McLauchlin  J, Grant  KA, Little  CL, Mithani  V, Penman  C, Changing pattern of human listeriosis, England and Wales, 2001–2004. Emerg Infect Dis. 2006;12:13616.PubMedGoogle Scholar
  4. Health Protection Agency. Cases: England and Wales, by month, 1990–2006: Listeria monocytogenes, human cases in residents of England and Wales by month reported to the Health Protection Agency Centre for Infections 1990–2006. 2008 [cited 2008 Jul 8]. Available from
  5. Health Protection Agency. Health protection report. Advice to pregnant women during the lambing season. 25 Jan. 2008;2(4) [cited 2008 Jul 8]. Available from
  6. UK Met Office. UK mean temperature (degrees C) areal series, starting from 1914 [database on the Internet]. UK Met Office; 2007 [updated monthly; cited 2007 May 31]. Available from
  7. D’Souza  RM, Becker  NG, Hall  G, Moodie  KB. Does ambient temperature affect foodborne disease? Epidemiology. 2004;15:8692. DOIPubMedGoogle Scholar
  8. Tam  CC, Rodrigues  LC, O’Brien  SJ, Hajat  S. Temperature dependence of reported campylobacter infection in England, 1989–1999. Epidemiol Infect. 2006;134:11925. DOIPubMedGoogle Scholar
  9. Burnham  KP, Anderson  DR. Model selection and multi-model inference, 2nd ed. New York: Springer; 2003.
  10. Holm  S. A simple sequentially rejective multiple test procedure. Scand J Stat. 1979;6:6570.
  11. Bentham  G, Langford  IH. Climate change and the incidence of food poisoning in England and Wales. Int J Biometeorol. 1995;39:816. DOIPubMedGoogle Scholar
  12. McLauchlin  J, Hall  SM, Velani  SK, Gilbert  RJ. Human listeriosis and paté: a possible association. BMJ. 1991;303:7735.PubMedGoogle Scholar
  13. Madders  B. Review of the livestock movement controls. Department for Environment, Food and Rural Affairs (UK); July 2006 [cited 2008 July 8]. Available from
  14. The Royal Society. Infectious diseases in livestock. London: The Society; July 2002 [cited 2008 Jul 8]. Available from
  15. Anderson  I. Foot and mouth disease 2001: lessons to be learned inquiry report. London: The Stationery Office; July 2002 [cited 2008 Jul 8]. Available from

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