Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 15, Number 3—March 2009
CME ACTIVITY - Research

Clinical Risk Factors for Severe Clostridium difficile–associated Disease

Timothy J. HenrichComments to Author , Douglas Krakower, Asaf Bitton, and Deborah S. Yokoe
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (T.J. Henrich, D. Krakower, A. Bitton, D.S. Yokoe); Massachusetts General Hospital, Boston (D. Krakower); Harvard Medical School, Boston (Deborah S. Yokoe)

Main Article

Table 5

Binary logistic regression model to identify independent associations of laboratory values and pertinent variables with severe CDAD, 285 patients*

Variable OR 95% CI
Age >70 y 3.24† 1.42–7.38
Female 1.16 0.51–2.62
Antimicrobial-drug use 1.04 0.35–3.12
Malignancy 0.90 0.37–2.18
Chemotherapy 1.02 0.27–3.92
Steroid use 1.13 0.48–2.68
Hemodialysis 0.5 0.8–3.01
Max leukocyte count >20,000/μL 2.77† 1.28–6.0
Max glucose level >150 mg/dL 1.46 0.63–3.43
ALT >40 U/L 1.47 0.58–3.69
Min albumin level <2.5 g/dL 3.44† 1.56–7.57
Max creatinine level >2 mg/dL 2.47† 1.04–5.88

*CDAD, Clostridium difficile–associated disease; OR, odds ratio; CI, confidence interval; max, maximum; ALT, alanine aminotransferase; min, minimum. Constant included in analysis.
†p<0.05.

Main Article

Page created: December 07, 2010
Page updated: December 07, 2010
Page reviewed: December 07, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external