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Volume 15, Number 5—May 2009
CME ACTIVITY - Research

Increased Risk for Severe Malaria in HIV-1–infected Adults, Zambia

Victor Chalwe, Doreen Mukwamataba, Joris Menten, John Kamalamba, Modest Mulenga, Umberto D’Alessandro, and Jean-Pierre Van GeertruydenComments to Author 
Author affiliations: Tropical Diseases Research Centre, Ndola, Zambia (V. Chalwe, D. Mukwamataba, M. Mulenga); Institute of Tropical Medicine, Antwerp, Belgium (J.-P. Van geertruyden, J. Menten, U. D’Alessandro); Thomson Hospital, Luanshya, Zambia (J. Kamalamba)

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Figure

Malaria endemicity in Zambia. This map is a product of the Mapping Malaria Risk in Africa/Atlas du Risque de la Malaria en Afrique (MARA/ARMA) collaboration (www.mara.org.za), July 2005. Malaria distribution was obtained from Craig et al. (14). Topographic data were obtained from African Data Sampler, World Resources Institute (www.igc.org/wri/sdis/maps/ads/ads_idx.htm).

Figure. Malaria endemicity in Zambia. This map is a product of the Mapping Malaria Risk in Africa/Atlas du Risque de la Malaria en Afrique (MARA/ARMA) collaboration (www.mara.org.za), July 2005. Malaria distribution was obtained from Craig et al. (14). Topographic data were obtained from African Data Sampler, World Resources Institute (www.igc.org/wri/sdis/maps/ads/ads_idx.htm).

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References
  1. Hewitt  K, Steketee  R, Mwapasa  V, Whitworth  J, French  N. Interactions between HIV and malaria in non-pregnant adults: evidence and implications. AIDS. 2006;20:19932004. DOIPubMedGoogle Scholar
  2. ter Kuile  FO, Parise  ME, Verhoeff  FH, Udhaya  KV, Newman  RD, van Eijk  AM, The burden of co-infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub-Saharan Africa. Am J Trop Med Hyg. 2004;71:4154.PubMedGoogle Scholar
  3. Whitworth  J, Morgan  D, Quigley  M, Smith  A, Mayanja  B, Eotu  H, Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet. 2000;356:10516. DOIPubMedGoogle Scholar
  4. French  N, Nakiyingi  J, Lugada  E, Watera  C, Whitworth  JA, Gilks  CF. Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. AIDS. 2001;15:899906. DOIPubMedGoogle Scholar
  5. Patnaik  P, Jere  CS, Miller  WC, Hoffman  IF, Wirima  J, Pendame  R, Effects of HIV-1 serostatus, HIV-1 RNA concentration, and CD4 cell count on the incidence of malaria infection in a cohort of adults in rural Malawi. J Infect Dis. 2005;192:98491. DOIPubMedGoogle Scholar
  6. Van geertruyden JP, Mulenga M, Mwananyanda L, Chalwe V, Moerman F, Chilengi R, et al. HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006;194:917–25.
  7. Diallo  AH, Ki-Zerbo  G, Sawadogo  AB, Guiguemde  TR. Severe malaria and HIV in adult patients in Bobo-Dioulasso, Burkina Faso [article in French]. Med Trop (Mars). 2004;64:34550.PubMedGoogle Scholar
  8. Grimwade  K, French  N, Mbatha  DD, Zungu  DD, Dedicoat  M, Gilks  CF. Childhood malaria in a region of unstable transmission and high human immunodeficiency virus prevalence. Pediatr Infect Dis J. 2003;22:105763. DOIPubMedGoogle Scholar
  9. Grimwade  K, French  N, Mbatha  DD, Zungu  DD, Dedicoat  M, Gilks  CF. HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa. AIDS. 2004;18:54754. DOIPubMedGoogle Scholar
  10. Cohen  C, Karstaedt  A, Frean  J, Thomas  J, Govender  N, Prentice  E, Increased prevalence of severe malaria in HIV-infected adults in South Africa. Clin Infect Dis. 2005;41:16317. DOIPubMedGoogle Scholar
  11. Khasnis  AA, Karnad  DR. Human immunodeficiency virus type 1 infection in patients with severe falciparum malaria in urban India. J Postgrad Med. 2003;49:1147.PubMedGoogle Scholar
  12. Chirenda  J, Siziya  S, Tshimanga  M. Association of HIV infection with the development of severe and complicated malaria cases at a rural hospital in Zimbabwe. Cent Afr J Med. 2000;46:59.PubMedGoogle Scholar
  13. Hayes  RJ, Marsh  K, Snow  RW. Case-control studies of severe malaria. J Trop Med Hyg. 1992;95:15766.PubMedGoogle Scholar
  14. Craig  MH, Snow  RW, le Sueur  D. A climate-based distribution model of malaria transmission in sub-Saharan Africa. Parasitol Today. 1999;15:10511. DOIPubMedGoogle Scholar
  15. Central Board of Health, Ministry of Health, Government of Republic of Zambia (GRZ). Zambia 2004 antenatal clinic sentinel surveillance. Lusaka (Zambia): GRZ; 2007.
  16. Severe falciparum malaria. World Health Organization, communicable diseases cluster. Trans R Soc Trop Med Hyg. 2000;94(Suppl 1):S190.PubMedGoogle Scholar
  17. Central Board of Health, Ministry of Health, Government of Republic of Zambia (GRZ). Zambia. Management of antiretroviral therapy. A reference manual for health workers. Lusaka (Zambia): GRZ; 2004.
  18. Janossy  G, Jani  I, Göhde  W. Affordable CD4(+) T-cell counts on ‘single-platform’ flow cytometers I. Primary CD4 gating. Br J Haematol. 2000;111:1198208. DOIPubMedGoogle Scholar
  19. Van geertruyden JP, Mulenga M, Kasongo W, Polman K, Colebunders R, Kestens L, et al. CD4 T-cell count and HIV-1 infection in adults with uncomplicated malaria. J Acquir Immune Defic Syndr. 2006;43:363–7.
  20. Butcher  GA. T-cell depletion and immunity to malaria in HIV-infections. Parasitology. 2005;130:14150. DOIPubMedGoogle Scholar
  21. Gilks  CF, Brindle  RJ, Otieno  LS, Simano  PM, Newnham  RS, Bhatt  SM, Life-threatening bacteraemia in HIV-1 seropositive adults admitted to hospital in Nairobi, Kenya. Lancet. 1990;336:5459. DOIPubMedGoogle Scholar
  22. Hay  SL, Guerra  CA, Tatem  AJ, Noor  AM, Snow  RW. The global distribution and population at risk of malaria: past, present, and future. Lancet Infect Dis. 2004;4:32736. DOIPubMedGoogle Scholar
  23. Mermin  J, Ekwaru  JP, Liechty  CA, Were  W, Downing  R, Ransom  R, Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet. 2006;367:125661. DOIPubMedGoogle Scholar

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