TY - JOUR AU - Angers, Rachel C. AU - Seward, Tanya S. AU - Napier, Dana AU - Green, Michael AU - Hoover, Edward AU - Spraker, Terry AU - O’Rourke, Katherine AU - Balachandran, Aru AU - Telling, Glenn C. T1 - Chronic Wasting Disease Prions in Elk Antler Velvet T2 - Emerging Infectious Disease journal PY - 2009 VL - 15 IS - 5 SP - 696 SN - 1080-6059 AB - Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency among cervids, we examined prion infectivity in the apical skin layer covering the growing antler (antler velvet) by using CWD-susceptible transgenic mice and protein misfolding cyclic amplification. Our finding of prions in antler velvet of CWD-affected elk suggests that this tissue may play a role in disease transmission among cervids. Humans who consume antler velvet as a nutritional supplement are at risk for exposure to prions. The fact that CWD prion incubation times in transgenic mice expressing elk prion protein are consistently more rapid raises the possibility that residue 226, the sole primary structural difference between deer and elk prion protein, may be a major determinant of CWD pathogenesis. KW - Prions and related diseases KW - prion proteins KW - elk KW - antler velvet KW - chronic wasting disease KW - expedited KW - research KW - United States KW - Canada DO - 10.3201/eid1505.081458 UR - https://wwwnc.cdc.gov/eid/article/15/5/08-1458_article ER - End of Reference