Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 15, Number 8—August 2009

Bordetella pertussis Strains with Increased Toxin Production Associated with Pertussis Resurgence

Frits R. MooiComments to Author , Inge H.M. van Loo, Marjolein van Gent, Qiushui He, Marieke J. Bart, Kees J. Heuvelman, Sabine C. de Greeff, Dimitri Diavatopoulos, Peter Teunis, Nico Nagelkerke, and Jussi Mertsola
Author affiliations: National Institute for Public Health and the Environment, Bilthoven, the Netherlands (F.R. Mooi, M. van Gent, M.J. Bart, K.J. Heuvelman, S.C. de Greeff, D. Diavatopoulos, P. Teunis); Maastricht University Hospital, Maastricht, the Netherlands (I.H.M. van Loo); National Public Health Institute, Turku, Finland (Q. He); United Arab Emirates University, Al Ain, United Arab Emirates (N. Nagelkerke); University of Turku, Turku (J. Mertsola)

Main Article

Table 3

Increases in illness and death caused by pertussis in 2 periods with low and high frequencies of ptxP3 strains in the Netherlands*

Parameter ptxP3 frequency, % Hospitalizations/100,000 Deaths/100,000 Lethality†
1981–1992 1.6 1.38 0.00057 0.00041
1993–2004 54.5 1.95 0.00582 0.00299
Increase 33.1 1.41 (1.34–1.49) 10.21 (1.31–79.11) 7.23 (0.93–56.07)
p value <0.0001 0.0058 0.03

*ptxP, pertussis toxin promoter. Numbers in parentheses are 95% confidence intervals.
†Lethality = no. of deaths / no. of hospitalizations.

Main Article

Page created: December 06, 2010
Page updated: December 06, 2010
Page reviewed: December 06, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.