TY - JOUR AU - Nordgren, Johan AU - Kindberg, Elin AU - Lindgren, Per-Eric AU - Matussek, Andreas AU - Svensson, Lennart T1 - Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 1 SP - 81 SN - 1080-6059 AB - Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46–4.36 vs. OR 0.71, 95% CI 0.23–2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes. KW - Norovirus KW - viruses KW - susceptibility KW - histo-blood group antigens KW - GI.3 KW - enteric infections KW - gastroenteritis KW - Sweden KW - research DO - 10.3201/eid1601.090633 UR - https://wwwnc.cdc.gov/eid/article/16/1/09-0633_article ER - End of Reference