TY - JOUR AU - Inoue, Masafumi AU - Barkham, Timothy AU - Leo, Yee-Sin AU - Chan, Kwai-Peng AU - Chow, Angela AU - Wong, Christopher W. AU - Lee, Raphael Tze-Chuen AU - Maurer-Stroh, Sebastian AU - Lin, Raymond AU - Lin, Cui T1 - Emergence of Oseltamivir-Resistant Pandemic (H1N1) 2009 Virus within 48 Hours T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 10 SP - 1633 SN - 1080-6059 AB - An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient’s exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo. KW - Influenza KW - pandemic (H1N1) 2009 KW - viruses KW - oseltamivir KW - antimicrobial resistance KW - Singapore KW - drug resistance KW - dispatch DO - 10.3201/eid1610.100688 UR - https://wwwnc.cdc.gov/eid/article/16/10/10-0688_article ER - End of Reference