Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 16, Number 11—November 2010
Dispatch

Enterovirus 71 Infection with Central Nervous System Involvement, South Korea

Wi-Sun Ryu, Byunghak Kang, Jiyoung Hong, Seoyeon Hwang, Ahyoun Kim, and Jonghyun Kim
Author affiliations: Seoul National University Hospital, Seoul, South Korea (W.-S. Ryu); Korea Centers for Disease Control and Prevention, Seoul (B. Kang, J. Hong, S. Hwang, A. Kim, D.S. Cheon); Catholic University College of Medicine, Suwon, South Korea (J. Kim)

Main Article

Table 2

Enterovirus 71 outbreaks, Asia*

Reference Outbreak location, year HFMD
 Complicated HFMD
 Genotypes
detected GenBank accession nos.
No.
patients No. patients with EV71 No.
patients No. patients
with EV71
Zhang et al. (10) Fuyang, PRC, 2008 151 59 112 42 C4a EU703812–14,
GQ121417–41
Zhang et al. (11) Shandong, PRC, 2007 105 55 11 6 C4a EU753365–417
AbuBakar et al. (1) Brunei, 2006 >100 34 NA NA B4, B5 FM201328–61
Ooi et al. (12) Sarawak,
Malaysia, 2000–2004 773 277 102 56 B4, C1, B5 AY905549–50,
AY794036,
AF376069
Lin et al. (13) Taiwan, 1998 NA NA 405 78 C2 AY055194–97,
FJ357343
This study South Korea, 2009 519 168 112 92 C4a, C1, C5 HM443164–644

*HFMD, hand-foot-and-mouth disease; EV71, enterovirus 71; PRC, People’s Republic of China; NA, not available.

Main Article

References
  1. AbuBakar  S, Sam  IC, Yusof  J, Lim  MK, Misbah  S, MatRahim N, et al. Enterovirus 71 outbreak, Brunei. Emerg Infect Dis. 2009;15:79–82. DOIPubMedGoogle Scholar
  2. Connolly  JH, O’Neill  HJ. Echovirus type 4 outbreak in Northern Ireland during 1970–71. Ulster Med J. 1972;41:155–60.PubMedGoogle Scholar
  3. Ooi  MH, Wong  SC, Clear  D, Perera  D, Krishnan  S, Preston  T, Adenovirus type 21–associated acute flaccid paralysis during an outbreak of hand-foot-and-mouth disease in Sarawak, Malaysia. Clin Infect Dis. 2003;36:550–9. DOIPubMedGoogle Scholar
  4. Cardosa  MJ, Perera  D, Brown  BA, Cheon  D, Chan  HM, Chan  KP, Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes. Emerg Infect Dis. 2003;9:461–8.PubMedGoogle Scholar
  5. Wang  JR, Tuan  YC, Tsai  HP, Yan  JJ, Liu  CC, Su  IJ. Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000. J Clin Microbiol. 2002;40:10–5. DOIPubMedGoogle Scholar
  6. McMinn  P, Lindsay  K, Perera  D, Chan  HM, Chan  KP, Cardosa  MJ. Phylogenetic analysis of enterovirus 71 strains isolated during linked epidemics in Malaysia, Singapore, and Western Australia. J Virol. 2001;75:7732–8. DOIPubMedGoogle Scholar
  7. Boom  R, Sol  JC, Salimans  MM, Jansen  CL, Wertheim-van Dillen  PM, van der Noordaa  J. Rapid and simple method for purification of nucleic acids. J Clin Microbiol. 1990;28:495–503.PubMedGoogle Scholar
  8. Tan  EL, Yong  LL, Quak  SH, Yeo  WC, Chow  VT, Poh  CL. Rapid detection of enterovirus 71 by real-time TaqMan RT-PCR. J Clin Virol. 2008;42:203–6. DOIPubMedGoogle Scholar
  9. Nix  WA, Oberste  MS, Pallansch  MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44:2698–704. DOIPubMedGoogle Scholar
  10. Zhang  Y, Zhu  Z, Yang  W, Ren  J, Tan  X, Wang  Y, An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand, foot and mouth disease in Fuyang city of China. Virol J. 2010;7:94. DOIPubMedGoogle Scholar
  11. Zhang  Y, Tan  XJ, Wang  HY, Yan  DM, Zhu  SL, Wang  DY, An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol. 2009;44:262–7. DOIPubMedGoogle Scholar
  12. Ooi  MH, Wong  SC, Podin  Y, Akin  W, del Sel  S, Mohan  A, Human enterovirus 71 disease in Sarawak, Malaysia: a prospective clinical, virological, and molecular epidemiological study. Clin Infect Dis. 2007;44:646–56. DOIPubMedGoogle Scholar
  13. Lin  TY, Chang  LY, Hsia  SH, Huang  YC, Chiu  CH, Hsueh  C, The 1998 enterovirus 71 outbreak in Taiwan: pathogenesis and management. Clin Infect Dis. 2002;34(Suppl 2):S52–7. DOIPubMedGoogle Scholar
  14. Perez-Velez  CM, Anderson  MS, Robinson  CC, McFarland  EJ, Nix  WA, Pallansch  MA, Outbreak of neurologic enterovirus type 71 disease: a diagnostic challenge. Clin Infect Dis. 2007;45:950–7. DOIPubMedGoogle Scholar
  15. Wang  SM, Liu  CC, Tseng  HW, Wang  JR, Huang  CC, Chen  YJ, Clinical spectrum of enterovirus 71 infection in children in southern Taiwan, with an emphasis on neurological complications. Clin Infect Dis. 1999;29:184–90. DOIPubMedGoogle Scholar

Main Article

Page created: March 03, 2011
Page updated: March 03, 2011
Page reviewed: March 03, 2011
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external