TY - JOUR AU - Principi, Nicola AU - Bosis, Samantha AU - Esposito, Susanna T1 - Effects of Coronavirus Infections in Children T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 2 SP - 183 SN - 1080-6059 AB - The isolation of the coronavirus (CoV) identified as the cause of severe acute respiratory syndrome and the detection of 2 new human CoVs (HCoV-NL63 and HCoV-HKU1) have led to studies of the epidemiology and clinical and socioeconomic effects of infections caused by all HCoVs, including those known since the late 1960s (HCoV-229E and HCoV-OC43). HCoV infections can be associated with respiratory and extrarespiratory manifestations, including central nervous system involvement. Furthermore, unlike other RNA viruses, HCoVs can easily mutate and recombine when different strains infect the same cells and give rise to a novel virus with unpredictable host ranges and pathogenicity. Thus, circulating HCoVs should be closely monitored to detect the spread of particularly virulent strains in the community at an early stage and to facilitate the development of adequate preventive and therapeutic measures. KW - Human coronaviruses KW - emerging viruses KW - respiratory viruses KW - SARS KW - childhood KW - viruses KW - perspective DO - 10.3201/eid1602.090469 UR - https://wwwnc.cdc.gov/eid/article/16/2/09-0469_article ER - End of Reference