TY - JOUR AU - Ilyushina, Natalia A. AU - Kim, Jeong-Ki AU - Negovetich, Nicholas J. AU - Choi, Young-Ki AU - Lang, Victoria AU - Bovin, Nicolai V. AU - Forrest, Heather L. AU - Song, Min-Suk AU - Pascua, Philippe Noriel Q. AU - Kim, Chul-Joong AU - Webster, Robert G. AU - Webby, Richard J. T1 - Extensive Mammalian Ancestry of Pandemic (H1N1) 2009 Virus T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 2 SP - 314 SN - 1080-6059 AB - We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus–like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir. The biological properties of these viruses are consistent with those of their phylogenetic progenitors, indicating longstanding adaptation to mammals. KW - Pandemic (H1N1) 2009 KW - H1N1 KW - hemagglutinin KW - receptor specificity KW - infectivity and transmission in avian species KW - viruses KW - influenza KW - expedited KW - dispatch KW - United States DO - 10.3201/eid1602.091141 UR - https://wwwnc.cdc.gov/eid/article/16/2/09-1141_article ER - End of Reference