Oseltamivir Resistance in Adult Oncology and Hematology Patients Infected with Pandemic (H1N1) 2009 Virus, Australia
Adrian R. Tramontana

, Biju George, Aeron C. Hurt, Joseph S. Doyle, Katherine Langan, Alistair B. Reid, Janet M. Harper, Karin Thursky, Leon J. Worth, Dominic E Dwyer, C. Orla Morrissey, Paul D.R. Johnson, Kirsty L. Buising, Simon James Harrison, John F. Seymour, Patricia E. Ferguson, Bin Wang, Justin T. Denholm, Allen C. Cheng, and Monica Slavin
Author affiliations: Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia (A.R. Tramontana, K. Thursky, L.J. Worth, S.J. Harrison, J.F. Seymour, M. Slavin); Western Hospital, Footscray, Victoria, Australia (A.R. Tramontana); Westmead Hospital, Sydney, New South Wales, Australia (B. George, D.E. Dwyer, B. Wang), World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt); The Alfred Hospital, Prahran, Victoria, Australia (J.S. Doyle, C.O. Morrissey); Austin Health, Heidelberg, Victoria, Australia (K. Langan, P.D.R. Johnson); St. Vincent’s Hospital, Melbourne, Victoria, Australia (A.B. Reid, K.L. Buising); Royal Melbourne Hospital, Melbourne (J.M. Harper, J.T. Denholm, M. Slavin); Centre for Infectious Diseases and Microbiology, Sydney (P.E. Ferguson); Monash University, Prahran (A.C. Cheng)
Main Article
Table 2
Characteristics of 4 patients infected with oseltamivir-resistant pandemic influenza A (H1N1) virus isolates, Australia*†
Characteristic |
Patient no.
|
1 |
5 |
12 |
20 |
Within 100 days of HSCT‡ |
No |
Yes |
No |
– |
Time to development of resistance, d |
22 |
11§ |
8 |
4 |
Time of last positive NAT result, d |
28 |
16 |
8 |
4 |
Change to zanamivir |
Yes |
No |
No |
No |
Time to zanamivir, d |
36 |
– |
– |
– |
Died |
Yes |
Yes |
No |
No |
LOS, d |
39 |
66 |
21 |
9 |
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Page created: March 02, 2011
Page updated: March 02, 2011
Page reviewed: March 02, 2011
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