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Volume 16, Number 8—August 2010

Correlation of Pandemic (H1N1) 2009 Viral Load with Disease Severity and Prolonged Viral Shedding in Children

Chung-Chen Li1, Lin Wang1, Hock-Liew Eng1, Huey-Ling You, Ling-Sai Chang, Kuo-Shu Tang, Ying-Jui Lin, Hsuan-Chang Kuo, Ing-Kit Lee, Jien-Wei Liu, Eng-Yen Huang, and Kuender D. YangComments to Author 
Author affiliations: Chang Gung Memorial Hospital–Kaohsiung Medical Center, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung

Main Article

Table 2

Factors associated with duration of viral shedding in 60 patients with pandemic (H1N1) 2009 virus infection, Taiwan*

Variable Viral RNA detected 7 d after symptom onset, % p value (UVA) HR (95% CI) p value (MVA)
Age (<13 vs. >13 y) 88.7 vs. 38.1 <0.001 4.99 (2.34–10.66) <0.001
Sex (M vs. F) 59.6 vs. 71.5 0.650 1.18 (0.57–2.44) 0.658
Disease severity (mild vs. severe)† 60.8 vs. 77.9 0.247 1.38 (0.56–3.45) 0.487
Time to initiate antiviral treatment (<48 h vs. >48 h) 60.6 vs. 81.8 0.176 2.56 (0.88–7.69) 0.085
Viral load from the first throat swab (<4.35 vs. >4.35 log10 copies/mL) 64.7 vs. 55.8 0.745 1.68 (0.64–4.37 0.292
Coexisting conditions (no vs. yes) 70.7 vs. 45.5 0.402 1.85 (0.78–4.39) 0.137

*UVA, univariate analysis; MVA, multivariate analysis; HR, hazard ratio; CI, confidence interval.
†Severe illness included pneumonia and meningoencephalitis; mild illness included upper respiratory tract infection and bronchitis.

Main Article

1These authors contributed equally to this article.

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