TY - JOUR AU - Feinstein, Lydia B. AU - Holman, Robert C. AU - Christensen, Krista L. Yorita AU - Steiner, Claudia A. AU - Swerdlow, David L. T1 - Trends in Hospitalizations for Peptic Ulcer Disease, United States, 1998–2005 T2 - Emerging Infectious Disease journal PY - 2010 VL - 16 IS - 9 SP - 1410 SN - 1080-6059 AB - Infection with Helicobacter pylori increases the risk for peptic ulcer disease (PUD) and its complications. To determine whether hospitalization rates for PUD have declined since antimicrobial drugs to eradicate H. pylori became available, we examined 1998–2005 hospitalization records (using the Nationwide Inpatient Sample) in which the primary discharge diagnosis was PUD. Hospitalizations for which the diagnosis was H. pylori infection were also considered. The age-adjusted hospitalization rate for PUD decreased 21% from 71.1/100,000 population (95% confidence interval [CI] 68.9–73.4) in 1998 to 56.5/100,000 in 2005 (95% CI 54.6–58.3). The hospitalization rate for PUD was highest for adults >65 years of age and was higher for men than for women. The age-adjusted rate was lowest for whites and declined for all racial/ethnic groups, except Hispanics. The age-adjusted H. pylori hospitalization rate also decreased. The decrease in PUD hospitalization rates suggests that the incidence of complications caused by H. pylori infection has declined. KW - peptic ulcer KW - duodenal ulcer KW - gastric ulcer KW - gastrojejunal ulcer KW - Helicobacter pylori KW - hospitalizations KW - enteric infections KW - bacteria KW - research KW - United States DO - 10.3201/eid1609.091126 UR - https://wwwnc.cdc.gov/eid/article/16/9/09-1126_article ER - End of Reference