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Volume 16, Number 9—September 2010

Worldwide Diversity of Klebsiella pneumoniae That Produce β-Lactamase blaKPC-2 Gene1

Gaëlle Cuzon, Thierry NaasComments to Author , HaVy Truong, Maria-Virginia Villegas, Karin T. Wisell, Yehuda Carmeli, Ana. C. Gales, Shiri Navon-Venezia, John P. Quinn, and Patrice Nordmann
Author affiliations: Author affiliations: Institut National de la Santé et de la Recherche Médicale, Paris, France (G. Cuzon, T. Naas, H. Truong, P. Nordmann); International Center for Medical Research and Training, Cali, Colombia (M.V. Villegas); Swedish Institute for Infectious Disease Control, Stockholm, Sweden (K.T. Wisell); Sourasky Medical Center, Tel Aviv, Israel (Y. Carmeli, S. Navon-Venezia); Universidade Federal de São Paulo, São Paulo, Brazil (A.C. Gales); John H. Stroger Jr. Hospital of Cook County, Chicago, Illinois, USA (J.P. Quinn); Chicago Infectious Disease Research Institute, Chicago (J.P. Quinn)

Main Article

Table 4

MICs of carbapenems for clinical Klebsiella pneumoniae isolates expressing KPC-2 β-lactamase*

Isolate type Carbapenem MIC, mg/L
Imipenem Meropenem Ertapenem
YC 4 2 24
GR 12 6 12
K271 4 4 16
KN2303 >32 >32 >32
KN633 >32 4 >32
INC H1521-6 6 3 8
INC H1516-6 4 4 32
HPTU 27635 4 2 12
HPTU 2020532 16 16 24
A28006 16 32 24
A28008 24 16 32
A28009 >32 >32 >32
A28011 >32 >32 >32
A33504 >32 >32 >32
475 16 >32 >32
588 24 16 32

*KPC, K. pneumoniae carbapenemase.

Main Article

1This study was presented in part at the Interscience Conference on Antimicrobial Agents and Chemotherapy; 2009 Sep 12–15; San Francisco, CA, USA.

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